Abstract
Because tissue repair mimics the cellular and molecular cascade of embryonic tissue formation, investigating the role of developmental pathways in joint and skeletal disorders/diseases could identify novel therapeutic targets.
Tissue repair and regeneration are partially determined by genetic factors.
Tissue engineering has adopted the concept of biomimetics of in vivo tissue development. Developmental engineering is the term used to describe novel methodology for the rational and accurate design of robust, well-controlled manufacturing processes of “biological spare parts.”
Cellular therapeutics and their combination products are complex with regard to their mechanism of action and manufacturing and have evolved into advanced therapy medicinal products with a specific regulatory path.
Recent advances in regenerative medicine and tissue engineering relevant to rheumatology have entered clinical practice and include the biologic repair of joint surface defects and bone healing.
Destruction of joint tissues is ultimately the disabling outcome of most forms of inflammatory or degenerative arthritides. The need for repair and regeneration of joints and joint-associated tissues is becoming more relevant as the dramatic advances of targeted treatments and improved disease management have allowed much more efficient control of inflammation and joint destruction.
In view of this situation, other aspects of joint biology deserve more attention—notably, and most importantly, the mechanisms driving tissue response and repair.1 Indeed, to restore the balance between tissue destruction and tissue repair (Figure 7-1), we should be looking at the more complete picture, that is, the “systems biology” of the joint as the organ of the rheumatologist. Introducing regenerative medicine provides a significant opportunity to restore joint homeostasis and thus possibly provide a cure. Targeting repair has entered our discipline, and investigating the potential to activate and enhance joint tissue repair mechanisms has become a prime goal.
Tissue repair and regeneration are partially determined by genetic factors.
Tissue engineering has adopted the concept of biomimetics of in vivo tissue development. Developmental engineering is the term used to describe novel methodology for the rational and accurate design of robust, well-controlled manufacturing processes of “biological spare parts.”
Cellular therapeutics and their combination products are complex with regard to their mechanism of action and manufacturing and have evolved into advanced therapy medicinal products with a specific regulatory path.
Recent advances in regenerative medicine and tissue engineering relevant to rheumatology have entered clinical practice and include the biologic repair of joint surface defects and bone healing.
Destruction of joint tissues is ultimately the disabling outcome of most forms of inflammatory or degenerative arthritides. The need for repair and regeneration of joints and joint-associated tissues is becoming more relevant as the dramatic advances of targeted treatments and improved disease management have allowed much more efficient control of inflammation and joint destruction.
In view of this situation, other aspects of joint biology deserve more attention—notably, and most importantly, the mechanisms driving tissue response and repair.1 Indeed, to restore the balance between tissue destruction and tissue repair (Figure 7-1), we should be looking at the more complete picture, that is, the “systems biology” of the joint as the organ of the rheumatologist. Introducing regenerative medicine provides a significant opportunity to restore joint homeostasis and thus possibly provide a cure. Targeting repair has entered our discipline, and investigating the potential to activate and enhance joint tissue repair mechanisms has become a prime goal.
| Original language | English |
|---|---|
| Title of host publication | Kelley and Firestein's Textbook of Rheumatology |
| Publisher | Elsevier |
| Chapter | 7 |
| Pages | 90-105.e4 |
| Volume | 1-2 |
| Edition | Tenth Edition |
| ISBN (Electronic) | 9780323316965 |
| ISBN (Print) | 9780323414982 |
| DOIs | |
| Publication status | Published - 2017 |