Fidelity of signal transduction relies on cells expressing the appropriate number of functional receptors. Fluctuation in the total number of muscarinic acetylcholine receptors has been implicated in a range of physiological and pathophysiological processes, and the mechanisms responsible for this regulation represent potential molecular targets for therapeutic intervention. This article will review the current literature on the endocytic trafficking of muscarinic receptors and how knowledge of the trafficking of related receptors might influence future studies.
First of all I would like to acknowledge the many authors whose work I have been unable to cover in this review. Focusing only on endocytic trafficking necessitated the omission of the many excellent studies on structure, signaling, allosteric modulation, dimerization, desensitization, arrestin interaction and biosynthetic trafficking, whose findings are critical to our understanding of the function of muscarinic acetylcholine receptors. Thanks go to Dawn Thompson for critical reading and advice on the manuscript. Diagram was drawn by the Medical Illustration Department at the University of Aberdeen. DZ is supported by a University of Aberdeen studentship and JNH is supported by the University of Aberdeen and Tenovus Scotland(G14/07).
- Journal Article