Regulation of intestinal growth in response to variations in energy supply and demand

K N Nilaweera* (Corresponding Author), J R Speakman* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)
9 Downloads (Pure)


The growth of the intestine requires energy, which is known to be met by catabolism of ingested nutrients. Paradoxically, during whole body energy deficit including calorie restriction, the intestine grows in size. To understand how and why this happens, we reviewed data from several animal models of energetic challenge. These were bariatric surgery, cold exposure, lactation, dietary whey protein intake and calorie restriction. Notably, these challenges all reduced the adipose tissue mass, altered hypothalamic neuropeptide expression and increased intestinal size. Based on these data, we propose that the loss of energy in the adipose tissue promotes the growth of the intestine via a signalling mechanism involving the hypothalamus. We discuss possible candidates in this pathway including data showing a correlative change in intestinal (ileal) expression of the cyclin D1 gene with adipose tissue mass, adipose derived-hormone leptin and hypothalamic expression of leptin receptor and the pro-opiomelanocortin gene. The ability of the intestine to grow in size during depletion of energy stores provides a mechanism to maximize assimilation of ingested energy and in turn sustain critical functions of tissues important for survival.

Original languageEnglish
Pages (from-to)61-72
Number of pages12
JournalObesity Reviews
Issue numberSuppl 1
Early online date3 Dec 2018
Publication statusPublished - Dec 2018

Bibliographical note

Biotechnology and Biological Sciences Research Council (BBSRC). Grant Number: BB/P009875/1
Science Foundation Ireland. Grant Number: SFI/16/BBSRC/3389


  • adipose tissue
  • hypothalamus
  • intestine


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