Abstract
Viruses exploit a number of strategies to evade immune recognition. In this study, we describe a novel mechanism by which EBV, rather than avoiding detection, subverts the immune response by stimulating regulatory T cells that secrete IL-10. Human PBMC from all EBV-seropositive, but not -seronegative, donors responded to both purified latent membrane protein 1 and the corresponding immunodominant peptides with high levels of IL-10 secretion by CD4+ T cells. These IL-10 responses, characteristic of T regulatory I cells, inhibited T cell proliferation and IFN-gamma secretion induced by both mitogen and recall Ag. It was confirmed that the inhibition was IL-10 dependent by the use of neutralizing Ab. The deviation of the immune response toward suppression is likely to be important in maintaining latency and EBV-associated tumors.
Original language | English |
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Pages (from-to) | 6183-6189 |
Number of pages | 6 |
Journal | The Journal of Immunology |
Volume | 170 |
Issue number | 12 |
Publication status | Published - Jun 2003 |
Keywords
- BARR-VIRUS EBV
- NF-KAPPA-B
- T-REGULATORY-1 CELLS
- CYTOKINE PRODUCTION
- NUCLEAR ANTIGEN-1
- EPITHELIAL-CELLS
- HELPER TYPE-1
- ENCODED LMP1
- IN-VITRO
- IDENTIFICATION