Rheumatoid arthritis association at 6q23

Wendy Thomson, Anne Barton, Xiayi Ke, Steve Eyre, Anne Hinks, John Bowes, Rachelle Donn, Deborah Symmons, Samantha Hider, Ian N. Bruce, Anthony G. Wilson, Ioanna Marinou, Ann Morgan, Paul Emery, Angela Carter, Sophia Steer, Lynne Hocking, David M Reid, Paul Wordsworth, Pille HarrisonDavid Strachan, Jane Worthington, Wellcome Trust Case Control Consortium

Research output: Contribution to journalArticlepeer-review

329 Citations (Scopus)


The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5)-5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated ( trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 ( TNFAIP3).

Original languageEnglish
Pages (from-to)1431-1433
Number of pages3
JournalNature Genetics
Issue number12
Early online date4 Nov 2007
Publication statusPublished - Dec 2007


  • population
  • responses
  • PTPN22
  • risk
  • gene
  • A20


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