Kaposi's sarcoma is a multifocal malignancy observed in elderly Mediterranean men (so-called Classic Kaposi's sarcoma), individuals in Africa (endemic Kaposi's sarcoma) and patients with immune disorders, including those undergoing organ transplantation (iatrogenic Kaposi's sarcoma) or infected with HIV (epidemic Kaposi's sarcoma). In all of these four clinical categories of Kaposi's sarcoma, the tumour represents aberrant angiogenesis or lymphangiogenesis (i.e. formation of new blood or lymphatic vessels, respectively ) through proliferation of spindle-shaped endothelial cells that line these vascular structures.
Research in D.J.B.'s laboratory is currently funded by Cancer Research UK and the Medical Research Council.