Abstract
Biology and HRESIMS-guided screening of the dichloromethane fraction of the marine sponge Phyllospongia lamellosa collected from the Red Sea resulted in the isolation and characterization of five new scalarane sesterterpenes; phyllospongins A–E (1–5), in addition to four known derivatives, 12α-acetoxy-20,24-dimethyl-25-norscalar-16-en-24-one (6), 12α-acetoxy-13β,18β-cyclobutan-20,24-dimethyl-24-oxoscalar-16-en-25β-ol (7), 12α-acetoxy-24,25-epoxy-24-hydroxy-20,24-dimethylscalarane (8), and scalardysin-A (9) that were previously isolated from Carteriospongia sp. and Dysidea sp. The structures of the isolated compounds were fully characterized using NMR spectroscopic techniques and mass spectrometric analysis. All the isolated compounds were tested for their cytotoxic activity against human cancer cell lines (HePG-2, MCF-7, and HCT-116) and antibacterial activity against some Gram-positive and Gram-negative strains.
Original language | English |
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Pages (from-to) | 577-583 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 71 |
Issue number | 4 |
Early online date | 13 Dec 2014 |
DOIs | |
Publication status | Published - 28 Jan 2015 |
Bibliographical note
AcknowledgementsThe authors would like to thank the Bioassay-Cell Culture Laboratory, National Research Centre, El-Tahrir St., Dokki, Cairo, Egypt for performing cytotoxic activity testing on different human cancer cell lines, Michelle Kelly, Department of Pharmacognosy, Pharmacology, Chemistry and Biochemistry and National Center for Natural Products Research, The University of Mississipi for primary identification of Phyllospongia lamellosa and the Finance and Development Unit of research projects, University of Beni-Suef for supporting our project No. 12/11.
Keywords
- scalarane sesterterpenes
- phyllospongia lamellosa
- phyllospongin
- cytotoxic
- antibacterial
- marine sponge
- carteriospongia-foliascens
- Indonesian sponge
- natural-products
- bishomoscalarane sesterterpenes
- homoscalarane sesterpenes
- strepsichordaia-aliena
- cacospongia-scalaris
- dereplication
- metabolites