Secreted frizzled-related protein 3 (sFRP3) regulates antidepressant responses in mice and humans

M. H. Jang, Y. Kitabatake, E. Kang, H. Jun, M. V. Pletnikov, K. M. Christian, R. Hen, S. Lucae, E. B. Binder* (Corresponding Author), H. Song* (Corresponding Author), G. I. Ming* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

23 Citations (Scopus)


Major depression, a common mental illness affecting millions of people worldwide, is one of the leading causes of morbidity and has a significant economic cost. Although the mechanisms of action are not well understood, antidepressants, including serotonin-selective reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs), have been used for the treatment of depression, anxiety and other psychiatric disorders.1 Here we identified a Wnt signaling inhibitor, secreted frizzled-related protein (sFRP3), as a molecular target of antidepressant treatments in rodent models, and revealed the significant association of three single-nucleotide polymorphisms (SNPs) in FRZB (the sFRP3 human ortholog) with early antidepressant responses in a clinical cohort.
Original languageEnglish
Pages (from-to)957-958
Number of pages2
JournalMolecular Psychiatry
Issue number9
Early online date4 Dec 2012
Publication statusPublished - 1 Sept 2013


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