Self-reported pain severity is associated with a history of coronary heart disease

S. Parsons, J. McBeth, G. J. Macfarlane, P. C. Hannaford, D. P. M. Symmons

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15 Citations (Scopus)
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Previous studies have found an association between chronic pain and cardiovascular (CV) mortality.

To explore the relationship between the severity of pain and non-fatal CV disease.

A total of 45,994 adults randomly selected from general practice registers in Manchester and Aberdeen were posted a survey, which included a Chronic Pain Grade questionnaire, pain manikin and questions about lifestyle and medical history. A single component measuring pain severity was extracted using factor analysis. Logistic regression was used to test for an association between quintiles of pain severity and a history of CV disease, adjusting for confounders.

Of the 15,288 responders, 61% (n = 9357) reported pain for ≥1 day in the past month. Compared with the first (lowest) pain severity quintile, the fully adjusted odds ratio for heart attack in the second severity quintile was 1.25 (95% confidence interval 0.68, 2.30); third quintile: 1.65 (0.93, 2.94); fourth quintile: 1.76 (1.00, 3.11) and fifth (highest) quintile 2.47 (1.43, 4.28). Corresponding figures for angina (excluding heart attack) were: 1.79 (0.93, 3.45), 1.91 (1.00, 3.62), 1.03 (0.50, 2.11) and 3.17 (1.71, 5.85).

A history of CV disease is reported more often in those with severe pain than would be expected by chance, even when adjusting for shared risk factors.
Original languageEnglish
Pages (from-to)167-175
Number of pages9
JournalEuropean Journal of Pain
Issue number2
Early online date28 May 2014
Publication statusPublished - Feb 2015

Bibliographical note

This study was funded by Arthritis Research UK (grant number: 17292).


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