Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: A MAPP Research Network study

Andrew Schrepf, David A. Williams, Robert Gallop, Bruce Naliboff, Neil Basu, Chelsea Kaplan, Daniel E. Harper, J. Richard Landis, J. Quentin Clemens, Eric Strachan, James W. Griffith, Niloofar Afari, Afton Hassett, Michael A. Pontari, Daniel J. Clauw, Steven E. Harte

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


Chronic Overlapping Pain Conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This ‘centralized pain’ phenotype has been described using a large and diverse set of symptom domains, including the spatial distribution of pain, pain intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, and hypersensitivity to external stimuli. Here we used three cohorts, including patients with Urologic Chronic Pelvic Pain Syndrome (UCPPS), a mixed pain cohort with other COPCs, and healthy individuals (total n = 1039) from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network to explore the factor structure of symptoms of centralized pain. Using exploratory and confirmatory factor analysis, we identified two general factors in all three cohorts, one characterized by a broad increased sensitivity to internal somatic sensations and environmental stimuli, and diffuse pain, termed Generalized Sensory Sensitivity (GSS), and one characterized by constitutional symptoms – Sleep, Pain, Affect, Cognition, Energy (SPACE). Longitudinal analyses in the UCPPS cohort found the same two factor structure at month six and one year, suggesting that the two factor structure is reproducible over time. In secondary analyses we found that GSS particularly is associated with the presence of comorbid COPCs, while SPACE shows modest associations with measures of disability and urinary symptoms. These factors may represent important and distinct continuum of symptoms that are indicative of the centralized pain phenotype at high levels. Future research of COPCs should accommodate the measurement of each factor.
Original languageEnglish
Pages (from-to)2002-2011
Number of pages10
Issue number10
Early online date28 May 2018
Publication statusPublished - 31 Oct 2018


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