Sex-differences in grey-white matter structure in normal-reading and dyslexic adolescents

Anca-Larisa Sandu-Giuraniuc* (Corresponding Author), Karsten Specht, Harald Beneventi , Arvid Lundervold, Kenneth Hugdahl

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


MR images were used to look for brain structure irregularities in adolescent children with dyslexia by use of combined grey and white matter volume measurements and fractal dimension (FD) of the grey–white matter border. The data were collected from 13 dyslexic adolescent (8 boys and 5 girls) that were compared with 18 control subjects (8 boys and 10 girls). The MR images were first segmented, and the volume as well as the FD of the grey/white matter border for the whole brain and for each hemisphere was computed. Changes were found in the measured volumes of both grey and white matter and were best reflected in the ratio of grey/white matter and in FD values, especially in the left hemisphere. The results showed that, although dyslexia is less frequent in women, the structural differences in the brain are more pronounced in their case, pointing to an increased vulnerability of the female brain to morphological changes associated with dyslexia.
Original languageEnglish
Pages (from-to)80-84
Number of pages5
JournalNeuroscience Letters
Issue number1
Early online date11 Apr 2008
Publication statusPublished - 13 Jun 2008
Externally publishedYes

Bibliographical note

The present study was supported financially by the Alfried Krupp von Bohlen und Halbach-Stiftung, Germany through a grant to Kenneth Hugdahl.

We thank Dr. Inge-Andre Rasmussen Jr. from the Institute of Psychiatry, University of Oslo, for valuable discussions and collaboration with data pre-processing.


  • Dyslexia
  • Gray matter/white matter ratio
  • Fractal dimension
  • Sex-differences
  • Morphometry


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