Speciation without Chromatography Using Selective Hydride Generation: Inorganic Arsenic in Rice and Samples of Marine Origin

Stanislav Musil, Ásta H Pétursdóttir, Andrea Raab, Helga Gunnlaugsdóttir, Eva Krupp, Jörg Feldmann* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Citations (Scopus)


Because of the toxicity of inorganic arsenic (iAs), only iAs needs to be monitored in food and feedstuff. This demands the development of easy and quick analytical methods to screen large number of samples. This work focuses on hydride generation (HG) coupled with an ICPMS as an arsenic detector where the HG is added as a selective step to determine iAs in the gaseous phase while organically bound As remains in the solution. iAs forms volatile arsine species with high efficiency when treated with NaBH4 at acidic conditions, whereas most other organoarsenic compounds do not form any or only less volatile arsines. Additionally, using high concentrations of HCl further reduces the production of the less volatile arsines and iAs is almost exclusively formed, therefore enabling to measure iAs without a prior step of species separation using chromatography. Here, we coupled a commercially available HG system to an ICPMS and optimized for determination of iAs in rice and samples of marine origin using different acid concentrations, wet and dry plasma conditions, and different reaction gas modes. Comparing this method to conventional HPLC-ICPMS, no statistical difference in iAs concentration was found and comparable limits of detections were achieved using less than half the instrument time.
Original languageEnglish
Pages (from-to)993-999
Number of pages7
JournalAnalytical Chemistry
Issue number2
Early online date9 Jan 2014
Publication statusPublished - 21 Jan 2014

Bibliographical note

The authors thank Agilent Technology for the loan of the 8800 ICPMS. Á. Pétursdóttir thanks the Icelandic research fund and the Icelandic research fund for graduate students for the financial support. S. Musil is grateful to Institute of Analytical Chemistry AS CR, v. v. i. (Institutional Research Plan RVO:68081715), to the Academy of Sciences of the Czech Republic (Project No. M200311271), and Journal Grant for International Authors programme by the Royal Society of Chemistry that sponsored his visit in the TESLA lab. Finnbogi Gudmundson is acknowledged for the dulse samples, and Cornelius Brombach is kindly thanked for the table of content/abstract graphic.


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