Spike timing-dependent plasticity induces non-trivial topology in the brain

R. R. Borges, F. S. Borges, E. L. Lameu, A. M. Batista, K. C. Iarosz, I. L. Caldas, C. G. Antonopoulos, M. S. Baptista

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)
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We study the capacity of Hodgkin-Huxley neuron in a network to change temporarily or permanently their connections and behavior, the so called spike timing-dependent plasticity (STDP), as a function of their synchronous behavior. We consider STDP of excitatory and inhibitory synapses driven by Hebbian rules. We show that the final state of networks evolved by a STDP depend on the initial network configuration. Specifically, an initial all-to-all topology envolves to a complex topology. Moreover, external perturbations can induce co-existence of clusters, those whose neurons are synchronous and those whose neurons are desynchronous. This work reveals that STDP based on Hebbian rules leads to a change in the direction of the synapses between high and low frequency neurons, and therefore, Hebbian learning can be explained in terms of preferential attachment between these two diverse communities of neurons, those with low-frequency spiking neurons, and those with higher-frequency spiking neurons.
Original languageEnglish
Pages (from-to)58–64
Number of pages7
JournalNeural Networks
Early online date31 Jan 2017
Publication statusPublished - 1 Apr 2017

Bibliographical note

This study was possible by partial financial support from the following Brazilian government agencies: CNPq, FAPESP (2011/19296-1, 2015/07311-7, 2016/16148-5) and CAPES. AMB, KCI, CGA, and MSB partial support from EPSRC-EP/I032606. We also wish thank Newton Fund and COFAP.


  • plasticity
  • synchronization
  • network


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