Stem and progenitor cells in synovium

Cosimo de Bari*, Anke J. Roelofs

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The synovium is a thin membrane that lines the cavity of synovial joints. It produces the synovial fluid for joint lubrication and cartilage nutrition. The adult synovium contains a heterogeneous population of mesenchymal stromal/stem cells (MSCs). A subset of MSCs in the joint that descends from the embryonic joint interzone naturally repairs articular cartilage defects in mice in vivo. MSCs in synovium are easy to access and attractive in regenerative cell-based therapy for cartilage repair and osteoarthritis via local delivery of exogenous MSCs or via pharmacological targeting of endogenous MSCs in the joint to trigger and enhance repair.
Original languageEnglish
Title of host publicationEncyclopedia of Bone Biology
EditorsMone Zaidi
Number of pages13
ISBN (Electronic)9780128140819
ISBN (Print)9780128140826
Publication statusPublished - 26 Jun 2020


  • Arthritis
  • articular cartilage
  • cell theraphy
  • fibroblasts
  • Mesenchymal stem cells
  • Regenerative medicine
  • repair
  • synovium
  • Tissue engineering


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