Abstract
During recovery, stroke patients are at risk of developing long-term complications that impact quality of life, including changes in body weight and composition, depression and anxiety, as well as an increased risk of subsequent vascular events. The aetiologies and time-course of these post-stroke complications have not been extensively studied and are poorly understood. Therefore, we assessed long-term changes in body composition, metabolic markers and behaviour after middle cerebral artery occlusion in mice. These outcomes were also studied in the context of obesity, a common stroke co-morbidity proposed to protect against post-stroke weight loss in patients. We found that stroke induced long-term changes in body composition, characterised by a sustained loss of fat mass with a recovery of lean weight loss. These global changes in response to stroke were accompanied by an altered lipid profile (increased plasma free fatty acids and triglycerides) and increased adipokine release at 60 days. After stroke, the liver also showed histological changes indicative of liver damage and a decrease in plasma alanine aminotransferase (ALT) was observed. Stroke induced depression and anxiety-like behaviours in mice, illustrated by deficits in exploration, nest building and burrowing behaviours. When initial infarct volumes were matched between mice with and without comorbid obesity, these outcomes were not drastically altered. Overall, we found that stroke induced long-term changes in depressive/anxiety-like behaviours, and changes in plasma lipids, adipokines and the liver that may impact negatively on future vascular health.
| Original language | English |
|---|---|
| Pages (from-to) | 837-850 |
| Number of pages | 14 |
| Journal | Translational Stroke Research |
| Volume | 11 |
| Early online date | 21 Dec 2019 |
| DOIs | |
| Publication status | Published - Aug 2020 |
Bibliographical note
AcknowledgementsWe would like to thank the Biological Services Facility at the University of Manchester for expert animal husbandry and Karen Davies who helped with the MRI. The Histology Facility equipment that was used in this study was purchased by the University of Manchester Strategic Fund. Special thanks goes to Peter Walker for their help with the histology.
Funding information
This work was supported by the Kohn Foundation, an Edward Bonham Carter Doctoral Scholarship, an EPSRC/MRC Centre for Doctoral Training in Regenerative Medicine studentship grant (EP/L014904/1), and the Medical Research Council (MR/K501311/1).
Keywords
- Brain ischaemia
- High-fat diet
- Adipokines
- Liver
- Lipids
- Depression
- CAUSE MORTALITY
- INDEPENDENT PREDICTOR
- RISK-FACTORS
- MASS INDEX
- WEIGHT-LOSS
- NATURAL-HISTORY
- SKELETAL-MUSCLE
- INFLAMMATION
- ACUTE ISCHEMIC-STROKE
- BRAIN
Access to Document
- Haley2020_Article_StrokeInducesProlongedChanges_VOR
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