Structural and functional brain changes in acute Takotsubo Syndrome

Hilal Khan; David Gamble; Amelia Rudd; Alice Mezincescu; Hassan Abbas; Awsan Noman; Andrew Stewart; Graham Horgan; Rajeev  Krishnadas; Christopher Williams; Gordon Waiter; Dana Dawson

doi:10.1016/j.jchf.2022.11.001

Structural and functional brain changes in acute Takotsubo Syndrome

Hilal Khan^* (Corresponding Author), David Gamble, Amelia Rudd, Alice Mezincescu, Hassan Abbas, Awsan Noman, Andrew Stewart, Graham Horgan, Rajeev Krishnadas, Christopher Williams, Gordon Waiter, Dana Dawson

^*Corresponding author for this work

University of Glasgow

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: Takotsubo syndrome mimics an acute myocardial infarction, typically in the aftermath of mental or physical stress.
Objectives: The mechanism by which emotional processing in the context of stress leads to significant cardiac injury is poorly understood, therefore a full exploration of brain structure and function in takotsubo syndrome patients merits investigation.
Methods: Twenty-five acute (< 5 days) takotsubo patients and 25 controls were recruited into this observational cross-sectional study. Surface-based morphometry was carried out on brain magnetic resonance imaging (MRI) scans to extract cortical morphology based on volume, thickness and surface area using Freesurfer. Cortical morphology general linear models were corrected for age, gender, photoperiod and total brain volume. Resting state functional MRI and diffusion tensor tractography images were pre-processed/analysed with
FMRIB’s Diffusion Toolbox/ CONN toolbox.
Results: There was significantly smaller total white matter and subcortical grey matter volumes in takotsubo (pConclusions: We showed smaller grey and white matter volumes driven by smaller cortical surface area, but increased cortical thickness and structural tractography connections with bidirectional changes in functional connectivity linked to emotion, language, reasoning,

Original language	English
Journal	JACC. Heart failure
Early online date	11 Jan 2023
DOIs	https://doi.org/10.1016/j.jchf.2022.11.001
Publication status	E-pub ahead of print - 11 Jan 2023

Bibliographical note

Acknowledgements
Professor Mark Petrie, Consultant Cardiologist, Glasgow, Dr David Corcoran, Consultant Cardiologist, Glasgow, Prof Stephen Leslie, Consultant Cardiologist, Inverness for identifying patients recruited in this study. We would like to acknowledge NHS Grampian Endowment EA9667/ES868, BHF Project Grant no. PG/18/35/33786, “Physical Exercise and mental wellbeing rehabilitation for Acute StrEss-induced takotsubo cardiomyopathy: The PLEASE trial and The Welcome Trust for supporting the work used in this study.

Keywords

cardiomyopathy
takotsubo
brain
Imaging

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Cite this

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title = "Structural and functional brain changes in acute Takotsubo Syndrome",

abstract = "Background: Takotsubo syndrome mimics an acute myocardial infarction, typically in the aftermath of mental or physical stress.Objectives: The mechanism by which emotional processing in the context of stress leads to significant cardiac injury is poorly understood, therefore a full exploration of brain structure and function in takotsubo syndrome patients merits investigation.Methods: Twenty-five acute (< 5 days) takotsubo patients and 25 controls were recruited into this observational cross-sectional study. Surface-based morphometry was carried out on brain magnetic resonance imaging (MRI) scans to extract cortical morphology based on volume, thickness and surface area using Freesurfer. Cortical morphology general linear models were corrected for age, gender, photoperiod and total brain volume. Resting state functional MRI and diffusion tensor tractography images were pre-processed/analysed withFMRIB{\textquoteright}s Diffusion Toolbox/ CONN toolbox.Results: There was significantly smaller total white matter and subcortical grey matter volumes in takotsubo (pConclusions: We showed smaller grey and white matter volumes driven by smaller cortical surface area, but increased cortical thickness and structural tractography connections with bidirectional changes in functional connectivity linked to emotion, language, reasoning, ",

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author = "Hilal Khan and David Gamble and Amelia Rudd and Alice Mezincescu and Hassan Abbas and Awsan Noman and Andrew Stewart and Graham Horgan and Rajeev Krishnadas and Christopher Williams and Gordon Waiter and Dana Dawson",

note = "Acknowledgements Professor Mark Petrie, Consultant Cardiologist, Glasgow, Dr David Corcoran, Consultant Cardiologist, Glasgow, Prof Stephen Leslie, Consultant Cardiologist, Inverness for identifying patients recruited in this study. We would like to acknowledge NHS Grampian Endowment EA9667/ES868, BHF Project Grant no. PG/18/35/33786, “Physical Exercise and mental wellbeing rehabilitation for Acute StrEss-induced takotsubo cardiomyopathy: The PLEASE trial and The Welcome Trust for supporting the work used in this study.",

year = "2023",

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doi = "10.1016/j.jchf.2022.11.001",

language = "English",

journal = "JACC. Heart failure",

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AU - Khan, Hilal

AU - Gamble, David

AU - Rudd, Amelia

AU - Mezincescu, Alice

AU - Abbas, Hassan

AU - Noman, Awsan

AU - Stewart, Andrew

AU - Horgan, Graham

AU - Krishnadas, Rajeev

AU - Williams, Christopher

AU - Waiter, Gordon

AU - Dawson, Dana

N1 - Acknowledgements Professor Mark Petrie, Consultant Cardiologist, Glasgow, Dr David Corcoran, Consultant Cardiologist, Glasgow, Prof Stephen Leslie, Consultant Cardiologist, Inverness for identifying patients recruited in this study. We would like to acknowledge NHS Grampian Endowment EA9667/ES868, BHF Project Grant no. PG/18/35/33786, “Physical Exercise and mental wellbeing rehabilitation for Acute StrEss-induced takotsubo cardiomyopathy: The PLEASE trial and The Welcome Trust for supporting the work used in this study.

PY - 2023/1/11

Y1 - 2023/1/11

N2 - Background: Takotsubo syndrome mimics an acute myocardial infarction, typically in the aftermath of mental or physical stress.Objectives: The mechanism by which emotional processing in the context of stress leads to significant cardiac injury is poorly understood, therefore a full exploration of brain structure and function in takotsubo syndrome patients merits investigation.Methods: Twenty-five acute (< 5 days) takotsubo patients and 25 controls were recruited into this observational cross-sectional study. Surface-based morphometry was carried out on brain magnetic resonance imaging (MRI) scans to extract cortical morphology based on volume, thickness and surface area using Freesurfer. Cortical morphology general linear models were corrected for age, gender, photoperiod and total brain volume. Resting state functional MRI and diffusion tensor tractography images were pre-processed/analysed withFMRIB’s Diffusion Toolbox/ CONN toolbox.Results: There was significantly smaller total white matter and subcortical grey matter volumes in takotsubo (pConclusions: We showed smaller grey and white matter volumes driven by smaller cortical surface area, but increased cortical thickness and structural tractography connections with bidirectional changes in functional connectivity linked to emotion, language, reasoning,

AB - Background: Takotsubo syndrome mimics an acute myocardial infarction, typically in the aftermath of mental or physical stress.Objectives: The mechanism by which emotional processing in the context of stress leads to significant cardiac injury is poorly understood, therefore a full exploration of brain structure and function in takotsubo syndrome patients merits investigation.Methods: Twenty-five acute (< 5 days) takotsubo patients and 25 controls were recruited into this observational cross-sectional study. Surface-based morphometry was carried out on brain magnetic resonance imaging (MRI) scans to extract cortical morphology based on volume, thickness and surface area using Freesurfer. Cortical morphology general linear models were corrected for age, gender, photoperiod and total brain volume. Resting state functional MRI and diffusion tensor tractography images were pre-processed/analysed withFMRIB’s Diffusion Toolbox/ CONN toolbox.Results: There was significantly smaller total white matter and subcortical grey matter volumes in takotsubo (pConclusions: We showed smaller grey and white matter volumes driven by smaller cortical surface area, but increased cortical thickness and structural tractography connections with bidirectional changes in functional connectivity linked to emotion, language, reasoning,

KW - cardiomyopathy

KW - takotsubo

KW - brain

KW - Imaging

U2 - 10.1016/j.jchf.2022.11.001

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C2 - 36752489

SN - 2213-1787

JO - JACC. Heart failure

JF - JACC. Heart failure

ER -

Structural and functional brain changes in acute Takotsubo Syndrome

Abstract

Bibliographical note

Keywords

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