Abstract
The effects of passive transfer of antisera containing cytotoxic antibodies to allo- and xenoantigens on survival of corneal allografts and xenografts were evaluated in experimental models. Corneas from allogeneic B 10 or xenogeneic rat Lewis donors were grafted orthotopically into BALB/c mice. Recipient mice were treated with donor-specific antisera administered at the period of grafting or at 2 weeks after transplantation. Rejection was determined by the severity of corneal opacity using a standard scoring system. Treatment of graft recipients with donor-specific antisera accelerated the onset of graft rejection and significantly shortened survival times of both corneal allografts and xenografts. Corneal xenografts, which had been accepted after treatment with anti-CD4 monoclonal antibody, were acutely rejected by the passive transfer of antiserum against xenoantigens. The results suggest that corneal grafts are vulnerable to antibody-dependent immunity and that cytotoxic antibodies against graft donor antigens can mediate rejection of both corneal allografts and xenografts. (c) 2005 Elsevier B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 211-213 |
Number of pages | 2 |
Journal | Immunology Letters |
Volume | 100 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2005 |
Keywords
- corneal transplantation
- allografts
- xenografts
- antibodies
- graft rejection
- GRAFT-REJECTION
- MOUSE MODEL
- TRANSPLANTATION
- RAT
- DESTRUCTION
- CELLS