Abstract
The amino acid glutamine has numerous important roles including particularly antioxidant defence, immune function, the inflammatory response, acid-base balance and N economy. The present systematic review of randomised controlled trials of nutrition support with glutamine Lip to August 2008 has found that parenteral glutamine in critical illness is associated with a non-significant reduction in mortality (risk ratio 0-71 (95% CI 0.49, 1.03)) and may reduce infections. However, poor study quality and the possibility of publication bias mean that these results should be interpreted with caution. There is no evidence to suggest that glutamine is harmful in terms of organ failure and parenteral glutamine may reduce the development of organ failure.
Original language | English |
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Pages (from-to) | 261-268 |
Number of pages | 8 |
Journal | Proceedings of the Nutrition Society |
Volume | 68 |
Issue number | 3 |
DOIs | |
Publication status | Published - Aug 2009 |
Keywords
- Glutamine
- Systematic review
- Critical illness
- PROSPECTIVE RANDOMIZED-TRIAL
- SEVERE ACUTE-PANCREATITIS
- MAJOR ABDOMINAL-SURGERY
- INFECTIOUS MORBIDITY
- DOUBLE-BLIND
- ENTERAL NUTRITION
- SURGICAL-PATIENTS
- CRITICAL ILLNESS
- ALANYL-GLUTAMINE
- CRITICAL-CARE
- Critial illness
- Parenteral nutrition
- Surgical procedures
- Operative