Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria

Margey Tadesse; Morten B. Strom; Johan Svenson; Marcel Jaspars; Bruce Forbes Milne; Veronika Torfoss; Jeanette H. Andersen; Espen Hansen; Klara Stensvag; Tor Haug

doi:10.1021/ol101707u

Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria

Margey Tadesse, Morten B. Strom, Johan Svenson, Marcel Jaspars, Bruce Forbes Milne, Veronika Torfoss, Jeanette H. Andersen, Espen Hansen, Klara Stensvag, Tor Haug

Chemistry

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.

Original language	English
Pages (from-to)	4752-4755
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	21
Early online date	30 Sept 2010
DOIs	https://doi.org/10.1021/ol101707u
Publication status	Published - 5 Nov 2010

Keywords

ANTIBACTERIAL
ADAREANUM

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10.1021/ol101707u

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title = "Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria",

abstract = "Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.",

keywords = "ANTIBACTERIAL, ADAREANUM",

author = "Margey Tadesse and Strom, {Morten B.} and Johan Svenson and Marcel Jaspars and Milne, {Bruce Forbes} and Veronika Torfoss and Andersen, {Jeanette H.} and Espen Hansen and Klara Stensvag and Tor Haug",

year = "2010",

month = nov,

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doi = "10.1021/ol101707u",

language = "English",

volume = "12",

pages = "4752--4755",

journal = "Organic Letters",

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TY - JOUR

T1 - Synoxazolidinones A and B

T2 - Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria

AU - Tadesse, Margey

AU - Strom, Morten B.

AU - Svenson, Johan

AU - Jaspars, Marcel

AU - Milne, Bruce Forbes

AU - Torfoss, Veronika

AU - Andersen, Jeanette H.

AU - Hansen, Espen

AU - Stensvag, Klara

AU - Haug, Tor

PY - 2010/11/5

Y1 - 2010/11/5

N2 - Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.

AB - Bioassay-guided fractionation of the sub-Arctic ascidian Synoicum pulmonaria collected off the Norwegian coast led to the isolation of a novel family of brominated guanidinium oxazolidinones named synoxazolidinones A and B (1 and 2). The backbone of the compounds contains a 4-oxazolidinone ring rarely seen in natural products. The structure of the compounds was determined by spectroscopic methods. The synoxazolidinones exhibited antibacterial and antifungal activities.

KW - ANTIBACTERIAL

KW - ADAREANUM

U2 - 10.1021/ol101707u

DO - 10.1021/ol101707u

M3 - Article

SN - 1523-7060

VL - 12

SP - 4752

EP - 4755

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Synoxazolidinones A and B: Novel Bioactive Alkaloids from the Ascidian Synoicum pulmonaria

Abstract

Keywords

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