Synthesis and characterisation of biologically compatible TiO2 nanoparticles

Richard William Cheyne, Timothy Andrew Davies Smith, Laurent Alain Claude Trembleau, Abbie McLaughlin

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We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation, these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance.

Original languageEnglish
Article number423
JournalNanoscale Research Letters
Issue number-
Early online date14 Jun 2011
Publication statusPublished - 2011


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