TY - JOUR
T1 - Synthesis and characterisation of biologically compatible TiO2 nanoparticles
AU - Cheyne, Richard William
AU - Smith, Timothy Andrew Davies
AU - Trembleau, Laurent Alain Claude
AU - McLaughlin, Abbie
PY - 2011
Y1 - 2011
N2 - We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation, these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance.
AB - We describe for the first time the synthesis of biocompatible TiO2 nanoparticles containing a functional NH2 group which are easily dispersible in water. The synthesis of water dispersible TiO2 nanoparticles coated with mercaptosuccinic acid is also reported. We show that it is possible to exchange the stearic acid from pre-synthesised fatty acid-coated anatase 5-nm nanoparticles with a range of organic ligands with no change in the size or morphology. With further organic functionalisation, these nanoparticles could be used for medical imaging or to carry cytotoxic radionuclides for radioimmunotherapy where ultrasmall nanoparticles will be essential for rapid renal clearance.
U2 - 10.1186/1556-276X-6-423
DO - 10.1186/1556-276X-6-423
M3 - Article
SN - 1556-276X
VL - 6
JO - Nanoscale Research Letters
JF - Nanoscale Research Letters
IS - -
M1 - 423
ER -