Abstract
In this paper, we describe the radiosynthesis of the compound (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene was carried out via C-11-methylation of (E)-2-(hydroxy)-3',4,5'-trimethoxystilbene by using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). (E)-2,3',4,5'-tetramethoxy[2-C-11]stilbene was obtained with a radiochemical purity greater than 95% in a 20 +/- 2% decay-corrected radiochemical yield, based upon [C-11]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1. 9 +/- 0.6 GBq/mu mol at EOB.
Original language | English |
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Pages (from-to) | 1206-1210 |
Number of pages | 5 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 50 |
Issue number | 13 |
Early online date | 19 Sept 2007 |
DOIs | |
Publication status | Published - Nov 2007 |
Keywords
- 2,3',4,5'-tetramethoxy[2-C-11]stilbene
- human cytochrome p4501b1
- expression
- aryl-hydrocarbon receptor
- CYP1B1
- PET
- inhibitors
- cancer
- potent
- tumors