Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules

Matteo Zanda, Stefano Altomonte

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The pentafluorosulphanyl group (SF5) is a highly stable chemical function which has been attracting a great deal of interest owing to its peculiar chemical, structural, physicochemical and biological properties. Progress in the area of SF5-compounds has been somewhat hindered by the lack of straightforward lab-scale synthetic methods for introducing the SF5-group into organic molecules. However, recent synthetic progress, the availability of some SF5-building blocks from commercial suppliers and the discovery of interesting properties of SF5-substituted molecules in materials science, biology and drug discovery are giving new momentum to research in this fascinating area of fluorine chemistry. Synthesis, reactivity and biological properties of SF5-substituted organic molecules are herein reviewed with an emphasis on the work published after year 2000.
Original languageEnglish
Pages (from-to)57-93
Number of pages38
JournalJournal of Fluorine Chemistry
Early online date11 Jul 2012
Publication statusPublished - Nov 2012

Bibliographical note

We thank the European Commission for financial support (Industry Academia Partnerships and Pathways project “PET BRAIN”, Contract No 251482). S.A. thanks the Northern Research Partnership ( and Pharmaness ( for co-funding a PhD studentship.


  • pentafluorosulphanyl group
  • review
  • synthesis
  • biological properties


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