Tako-Tsubo Cardiomyopathy: A Heart Stressed Out of Energy?

Dana K Dawson, Christopher J Neil, Anke Henning, Donnie Cameron, Baljit Jagpal, Margaret Bruce, John Horowitz, Michael P Frenneaux

Research output: Contribution to journalLetterpeer-review

57 Citations (Scopus)


Tako-tsubo cardiomyopathy (TTC) is an acute form of left ventricular (LV) systolic dysfunction often following intense stress, but its pathophysiology remains elusive. Because of its reversible natural course without much apparent myocyte damage, as inferred by the lack of late gadolinium-enhanced (LGE) cardiac magnetic resonance (CMR), it has been a priori assumed that its evolution is benign (1). Whatever the etiology of the acute insult, it is important to establish the nature of this state of intense myocardial contractile dysfunction with preserved viability, as this may point to a potential therapeutic target in those cases with a less favorable clinical course. It is known that impaired cardiac energetic status is directly linked to clinical and subclinical LV dysfunction. We hypothesized that impaired cardiac energetics may occur in acute TTC, further investigating its recovery at 4 months follow-up.
Original languageEnglish
Pages (from-to)985-987
Number of pages3
JournalJACC. Cardiovascular Imaging
Issue number8
Early online date1 Nov 2014
Publication statusPublished - Aug 2015

Bibliographical note

The authors thank all their NHS consultant colleagues at Aberdeen Royal Infirmary for their help with prompt recruitment of these patients (Dr. Malcolm Metcalfe, Dr. Andrew Stewart, Dr. Andrew Hannah, Dr. Awsan Noman, Dr. Paul Broadhurst, Dr. Duncan Hogg, Dr. Deepak Garg) and to Dr. Caroline Scally, specialist cardiology trainee, for special effort with recruitment. Thanks also go to Ms. Bernice Kai Ng, medical student, for her initial work with cardiac spectroscopy in healthy volunteers and data entry.


  • Tako-tsubo cardiomyopathy
  • Left ventricular systolic dysfunction


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