Tamoxifen, angiogenesis, oestrogens and animal models

Valerie Speirs*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Angiogenesis is the remodelling of existing vasculature either by formation of new blood vessels or regression of superfluous vessels. In normal adults there is relatively little angiogenesis, but it is well documented that neovascularisation is required for tumour growth beyond a critical size. The (ER) antagonist TAM is currently the first line therapy for treatment of hormone sensitive breast cancer. However, besides its anti-oestrogenic effects, TAM has also been shown to have anti-angiogenic properties. Although there has been much work on the former, the anti-angiogenic actions of TAM are not well understood.
Original languageEnglish
Article number66721
JournalBreast Cancer Research
Issue number1
Publication statusPublished - 22 Jan 2001
Externally publishedYes


  • Angiogenesis
  • Oestrogen receptor
  • TAM


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