Abstract
Incubation of rat hippocampal slices with the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation of field excitatory postsynaptic potentials recorded in the CA1 region. However, in slices incubated with its non-psychoactive(+)-isomer HU-211 (100 nM), which is reported to be an NMDA receptor antagonist, high frequency stimulation evoked a long-lasting potentiation, comparable to control slices.
Original language | English |
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Pages (from-to) | R7-R8 |
Number of pages | 2 |
Journal | European Journal of Pharmacology |
Volume | 259 |
Issue number | 3 |
Publication status | Published - 1994 |
Keywords
- CANNABINOID
- LONG-TERM POTENTIATION
- HIPPOCAMPUS
- cannabinoid
- drug of abuse
- toxicity
- mechanism of action
- memeory disorder
- rat
- animal
- NMDA receptor
- antagonist
- long term
- potentiation
- electrophysiology
- in vitro
- synthetic product
- hippocampus
- brain (vertebrate)
- central nervous system
- rodentia
- mammalia
- vertebrata