The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan tegella cf. spitzbergensis

Margey Tadesse; Jioji N. Tabudravu; Marcel Jaspars; Morten B. Strøm; Espen Hansen; Jeanette H. Andersen; Per E. Kristiansen; Tor Haug

doi:10.1021/np100499c

The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan tegella cf. spitzbergensis

Margey Tadesse^*, Jioji N. Tabudravu, Marcel Jaspars, Morten B. Strøm, Espen Hansen, Jeanette H. Andersen, Per E. Kristiansen, Tor Haug

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.

Original language	English
Pages (from-to)	837-841
Number of pages	5
Journal	Journal of Natural Products
Volume	74
Issue number	4
DOIs	https://doi.org/10.1021/np100499c
Publication status	Published - 25 Apr 2011

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title = "The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan tegella cf. spitzbergensis",

abstract = "The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.",

author = "Margey Tadesse and Tabudravu, {Jioji N.} and Marcel Jaspars and Str{\o}m, {Morten B.} and Espen Hansen and Andersen, {Jeanette H.} and Kristiansen, {Per E.} and Tor Haug",

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doi = "10.1021/np100499c",

language = "English",

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T1 - The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan tegella cf. spitzbergensis

AU - Tadesse, Margey

AU - Tabudravu, Jioji N.

AU - Jaspars, Marcel

AU - Strøm, Morten B.

AU - Hansen, Espen

AU - Andersen, Jeanette H.

AU - Kristiansen, Per E.

AU - Haug, Tor

PY - 2011/4/25

Y1 - 2011/4/25

N2 - The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.

AB - The brominated tryptophan-derived ent-eusynstyelamide B (1) and three new derivatives, eusynstyelamides D, E, and F (2-4), were isolated from the Arctic bryozoan Tegella cf. spitzbergensis. The structures were elucidated by spectroscopic methods including 1D and 2D NMR and analysis of mass spectrometric data. The enantiomer of 1, eusynstyelamide B, has previously been isolated from the Australian ascidian Eusynstyela latericius. Antimicrobial activities are here reported for 1-4, with minimum inhibitory concentrations (MIC) as low as 6.25 μg/mL for 1 and 4 against Staphylococcus aureus. Eusynstyelamides 2 and 3 showed weak cytotoxic activity against the human melanoma A 2058 cell line.

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The antibacterial ent-eusynstyelamide B and eusynstyelamides D, E, and F from the arctic bryozoan tegella cf. spitzbergensis

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