The evolution of IL-4 and IL-13 and their receptor subunits

Tiehui Wang, Christopher J. Secombes* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Citations (Scopus)
12 Downloads (Pure)


This review will outline what is known about the origins and evolution of type 2 cytokines and their receptors in vertebrates. It takes advantage of the recent advances made in gene identification from the many vertebrate genomes that have now been sequenced. It will also describe what functional studies have been performed to date, giving clues to the role of these molecules and signalling pathways in non-mammalian vertebrates.
Original languageEnglish
Pages (from-to)8-13
Number of pages6
Issue number1
Early online date21 May 2015
Publication statusPublished - Sept 2015


  • IL-4/IL-13 evolution
  • IL-4R/IL-13R receptor evolution
  • IL-4/13 molecules


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