The evolution of spliced leader trans-splicing in nematodes

Jonathan Pettitt, Neale Harrison, Ian Stansfield, Bernadette Connolly, Berndt Müller

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Spliced leader trans-splicing occurs in many primitive eukaryotes including nematodes. Most of our knowledge of trans-splicing in nematodes stems from the model organism Caenorhabditis elegans and relatives, and from work with Ascaris. Our investigation of spliced leader trans-splicing in distantly related Dorylaimia nematodes indicates that spliced-leader trans-splicing arose before the nematode phylum and suggests that the spliced leader RNA gene complements in extant nematodes have evolved from a common ancestor with a diverse set of spliced leader RNA genes.
Original languageEnglish
Pages (from-to)1125-1130
Number of pages6
JournalBiochemical Society Transactions
Issue number4
Publication statusPublished - Aug 2010


  • animals
  • base sequence
  • evolution, molecular
  • models, biological
  • molecular sequence data
  • nematoda
  • nucleic acid conformation
  • phylogeny
  • RNA splice sites
  • RNA, spliced leader
  • trans-splicing


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