The fluorinase from Streptomyces cattleya is also a chlorinase

Hai Deng; Steven L.  Cobb; Andrew R McEwan; Ryan P. McGlinchey; James H. Naismith; David O'hagan; David A. Robinson; Jonathan B Spencer

doi:10.1002/anie.200503582

The fluorinase from Streptomyces cattleya is also a chlorinase

Hai Deng, Steven L. Cobb, Andrew R McEwan, Ryan P. McGlinchey, James H. Naismith, David O'hagan (Corresponding Author), David A. Robinson, Jonathan B Spencer

Chemistry

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a CF bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination.

Original language	English
Pages (from-to)	759-762
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	45
Issue number	5
Early online date	21 Dec 2005
DOIs	https://doi.org/10.1002/anie.200503582
Publication status	Published - 23 Jan 2006

Keywords

chlorinase
enzyme catalysis
fluorinase
halogenation
S‐adenosylmethionine

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abstract = "Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a CF bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination.",

keywords = "chlorinase, enzyme catalysis, fluorinase, halogenation, S‐adenosylmethionine",

author = "Hai Deng and Cobb, {Steven L.} and McEwan, {Andrew R} and McGlinchey, {Ryan P.} and Naismith, {James H.} and David O'hagan and Robinson, {David A.} and Spencer, {Jonathan B}",

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AU - Deng, Hai

AU - Cobb, Steven L.

AU - McEwan, Andrew R

AU - McGlinchey, Ryan P.

AU - Naismith, James H.

AU - O'hagan, David

AU - Robinson, David A.

AU - Spencer, Jonathan B

PY - 2006/1/23

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AB - Choices choices: The fluorinase enzyme from Streptomyces cattleya (catalyzes the formation of a CF bond from fluoride ions) also has the capacity to utilize a chloride ion although it has a clear preference for the fluoride ion. The enzyme mediates a nucleophilic chlorination reaction, which is an unusual mechanism for enzymatic chlorination.

KW - chlorinase

KW - enzyme catalysis

KW - fluorinase

KW - halogenation

KW - S‐adenosylmethionine

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DO - 10.1002/anie.200503582

M3 - Article

C2 - 16370017

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SP - 759

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JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 5

ER -

The fluorinase from Streptomyces cattleya is also a chlorinase

Abstract

Keywords

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