The genetic portrait of an outbreak strain

Hasan Yesilkaya, Ken J. Forbes, Jamila Shafi, Rebecca Smith, Jeremy W Dale, Kumar Rajakumar, Michael R. Barer, Peter W. Andrew

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ten IS6110 insertion sites in the genome of the M. tuberculosis CH strain, which was responsible for a large outbreak in Leicestershire, England. Together with previous data on genomic deletions, it was found that 16 genes were mutated either by IS6110 insertions or deletions. The likely impact of these genomic events on the phenotype of the CH strain is discussed. (c) 2005 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)357-362
Number of pages6
Issue number5
Publication statusPublished - Sept 2006


  • Mycobacterium tuberculosis
  • CH strain
  • outbreak
  • insertion
  • deletion
  • IS6110
  • mycobacterium-tuberculosis complex
  • nucleotide polymorphisms
  • clinical isolate
  • immune-response
  • virulence
  • genomes
  • infection
  • macrophages
  • mutagenesis
  • organisms


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