Abstract
Objective
High-fat diets cause obesity in male mice; however, the underlying mechanisms remain controversial. Here, three contrasting ideas were assessed: hedonic overdrive, reverse causality, and passive overconsumption models.
Methods
A total of 12 groups of 20 individually housed 12-week-old C57BL/6 male mice were exposed to 12 high-fat diets with varying fat content from 40% to 80% (by calories), protein content from 5% to 30%, and carbohydrate content from 8.4% to 40%. Body weight and food intake were monitored for 30 days after 7 days at baseline on a standard low-fat diet.
Results
After exposure to the diets, energy intake increased first, and body weight followed later. Intake then declined. The peak energy intake was dependent on both dietary protein and carbohydrate, but not the dietary fat and energy density, whereas the rate of decrease in intake was only related to dietary protein. On high-fat diets, the weight of food intake declined, but despite this average reduction of 14.4 g in food intake, they consumed, on average, 357 kJ more energy than at baseline.
Conclusions
The hedonic overdrive model fit the data best. The other two models were not supported.
Original language | English |
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Pages (from-to) | 733-742 |
Number of pages | 10 |
Journal | Obesity |
Volume | 32 |
Issue number | 4 |
Early online date | 27 Feb 2024 |
DOIs | |
Publication status | Published - Apr 2024 |
Bibliographical note
Open Access via the Wiley AgreementNational Key R&D Program of China. Grant Number: 2019YFA0801900
Chinese Academy of Sciences. Grant Number: XDB13030100
National Science Foundation of China. Grant Number: 92057206