The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

Sinan Khadhouri; Kevin M. Gallagher; Kenneth MacKenzie; Taimur T. Shah; Chuanyu Gao; Sacha Moore; Eleanor Zimmermann; Eric Edison; Matthew Jefferies; Arjun K. Nambiar; Miles  Mannas; Taeweon  Lee; Giancarlo  Marra; Beatrice  Lillaz; Juan Gómez Rivas; Jonathan  olivier; Mark  Assmus; Taha  Uçar; Francesco  Claps; Matteo  Boltri; Tara  Burnhope; Nkwam  Nkwam; George  Tanasescu; Nicholas  Boxall; Alison  Downey; Asim  Lal; Marta  Antón-Juanilla; Holly  Clarke; David  Lau; Kathryn  Gillams; Matthew  Crockett; Matthew E.  Nielsen; Yemisi Takwoingi; Naomi  Chuchu; John  O'Rourke; Graeme MacLennan; John McGrath; Veeru Kasivisvanathan; The IDENTIFY Study Group

doi:10.1111/bju.15483

The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

Sinan Khadhouri^* (Corresponding Author), Kevin M. Gallagher, Kenneth MacKenzie, Taimur T. Shah, Chuanyu Gao, Sacha Moore, Eleanor Zimmermann, Eric Edison, Matthew Jefferies, Arjun K. Nambiar, Miles Mannas, Taeweon Lee , Giancarlo Marra , Beatrice Lillaz , Juan Gómez Rivas, Jonathan olivier, Mark Assmus , Taha Uçar, Francesco Claps, Matteo Boltri Tara Burnhope, Nkwam Nkwam, George Tanasescu, Nicholas Boxall, Alison Downey , Asim Lal, Marta Antón-Juanilla , Holly Clarke, David Lau, Kathryn Gillams , Matthew Crockett, Matthew E. Nielsen, Yemisi Takwoingi, Naomi Chuchu , John O'Rourke, Graeme MacLennan, John McGrath, Veeru Kasivisvanathan, The IDENTIFY Study Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer (UTUC) and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. This was an international multicentre prospective observational study. We included patients aged 16 and over, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex and smoking. We used a multivariable mixed effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals and countries. Of the 11,059 patients assessed for eligibility, 10,896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n=2257) was 28.2% (95% CI 22.3-34.1), bladder cancer (n=1951) 24.7% (19.1-30.2), UTUC (n=128) 1.14% (0.77-1.52), renal cancer (n=107) 1.05% (0.80-1.29) and prostate cancer (n=124) 1.75% (1.32-2.18). Odds ratios for patient risk markers in the model for all cancers were: Age 1.04 (95% CI 1.03-1.05) p

Original language	English
Pages (from-to)	440-450
Number of pages	12
Journal	BJU International
Volume	128
Issue number	4
Early online date	8 Sept 2021
DOIs	https://doi.org/10.1111/bju.15483
Publication status	Published - 1 Oct 2021

Bibliographical note

Funding
Grants from Action Bladder Cancer UK, The Urology Foundation, The Rosetrees Trust were used for costs of statistical analysis and dissemination of results at international meetings and conferences. There were no endorsements from pharmaceutical companies or agencies to write this article. The corresponding author (Sinan Khadhouri) had full access to the data and held the final responsibility to submit the manuscript. Action Bladder Cancer UK, The Urology Foundation, The Rosetrees Trust.

Keywords

haematuria
bladder cancer
upper tract urothelial cancer
renal cancer
cancer prevalence
urinary tract cancer
prostate cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Khadhouri_etal_BJUI_The_IDENTIFY_study_VOR
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Khadhouri, S., Gallagher, K. M., MacKenzie, K., Shah, T. T., Gao, C., Moore, S., Zimmermann, E., Edison, E., Jefferies, M., Nambiar, A. K., Mannas, M., Lee , T., Marra , G., Lillaz , B., Gómez Rivas, J., olivier, J., Assmus , M., Uçar, T., Claps, F., ... The IDENTIFY Study Group (2021). The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study. BJU International, 128(4), 440-450. https://doi.org/10.1111/bju.15483

The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study. / Khadhouri, Sinan (Corresponding Author); Gallagher, Kevin M.; MacKenzie, Kenneth et al.
In: BJU International, Vol. 128, No. 4, 01.10.2021, p. 440-450.

Research output: Contribution to journal › Article › peer-review

Khadhouri, S, Gallagher, KM, MacKenzie, K, Shah, TT, Gao, C, Moore, S, Zimmermann, E, Edison, E, Jefferies, M, Nambiar, AK, Mannas, M, Lee , T, Marra , G, Lillaz , B, Gómez Rivas, J, olivier, J, Assmus , M, Uçar, T, Claps, F, Boltri , M, Burnhope, T, Nkwam, N, Tanasescu, G, Boxall, N, Downey , A, Lal, A, Antón-Juanilla , M, Clarke, H, Lau, D, Gillams , K, Crockett, M, Nielsen, ME, Takwoingi, Y, Chuchu , N, O'Rourke, J, MacLennan, G, McGrath, J, Kasivisvanathan, V & The IDENTIFY Study Group 2021, 'The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study', BJU International, vol. 128, no. 4, pp. 440-450. https://doi.org/10.1111/bju.15483

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The IDENTIFY Study: The Investigation and Detection of Urological Neoplasia in Patients Referred with Suspected Urinary Tract Cancer; A multicentre observational study

Abstract

Bibliographical note

Keywords

UN SDGs

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