Design: A two-centre observational study including vaccinated and unvaccinated women.
Setting: Colposcopy clinics serving two health regions in Scotland, UK.
Population: 361 women aged 20-25 years attending colposcopy following an abnormal cervical cytology result at routine cervical screening.
Methods: Cervical samples were obtained from women for HPV DNA genotyping and mRNA E6/E7 expression of HPV 16,18,31,33 and 45. Demographic data, cytology and histology results and colposcopic features were recorded. Chi squared analysis was conducted to identify associations between vaccine status, HPV genotypes and colposcopic features.
|Number of pages||8|
|Journal||BJOG-An International Journal of Obstetrics and Gynaecology|
|Early online date||9 Mar 2017|
|Publication status||Published - Aug 2017|
Bibliographical noteAcknowledgements& Funding
We would like to offer our sincere thanks to all the women who participated in this study and to the staff at NHS sites who facilitated this study.
This study was funded by a CSO Programme grant (CSO reference number CZH/4/528) and NHS Grampian endowment grants. AM was awarded a bursary from The Jean Shanks Foundation for her contribution to this study.
- HPV genotyping
- cervical screening
- HPV vaccine
- cervical intraepithelial neoplasia
- human papillomavirus
- human papillomavirus genotyping
- human papillomavirus vaccine