The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

Nishat Siddiqi; Christopher J. Neil; Jagpal Baljit; Jemma Hudson; Michael P. Frenneaux; Dana K. Dawson

doi:10.1186/1532-429X-17-S1-P149

The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

Nishat Siddiqi^*, Christopher J. Neil, Jagpal Baljit, Jemma Hudson, Michael P. Frenneaux, Dana K. Dawson

^*Corresponding author for this work

University of Aberdeen

Research output: Contribution to journal › Abstract › peer-review

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Abstract

Background
Infarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.

Methods
55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.

Original language	English
Pages (from-to)	149-150
Number of pages	2
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	17
Issue number	Supplement 1
DOIs	https://doi.org/10.1186/1532-429X-17-S1-P149
Publication status	Published - 3 Feb 2015

Bibliographical note

Funding
This project was funded by a grant from the MRC(UK).

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10.1186/1532-429X-17-S1-P149Licence: CC BY

impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR
© Siddiqi et al; licensee BioMed Central Ltd. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 405 KBLicence: CC BY

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The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR. / Siddiqi, Nishat; Neil, Christopher J.; Baljit, Jagpal et al.
In: Journal of Cardiovascular Magnetic Resonance, Vol. 17, No. Supplement 1, 03.02.2015, p. 149-150.

Research output: Contribution to journal › Abstract › peer-review

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abstract = "BackgroundInfarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.Methods55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.",

author = "Nishat Siddiqi and Neil, {Christopher J.} and Jagpal Baljit and Jemma Hudson and Frenneaux, {Michael P.} and Dawson, {Dana K.}",

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AU - Hudson, Jemma

AU - Frenneaux, Michael P.

AU - Dawson, Dana K.

N1 - Funding This project was funded by a grant from the MRC(UK).

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N2 - BackgroundInfarct size (IS) is one of the most important predictors of outcome after acute myocardial infarction (AMI) and can be detected in vivo with Late Enhancement CMR (LGE). However, the most consistent method of LGE quantification is yet to be determined.Methods55 patients with reperfused, first acute ST-elevation AMI underwent LGE-CMR on a Philips Achieva 3T scanner at 1 week and 6 months post AMI. IS was expressed as a percentage of LV volume and measured at both time points using: manual planimetry, signal intensity threshold indicating LGE set at 2, 3 and 5 standard deviations (SD) above the remote myocardium and the full width at half maximum (FWHM) technique, which uses half the maximal signal within the scar as the threshold. The relationship between all measures of IS and final (6 month) LV ejection fraction (LV EF) and LV end diastolic volume (LV EDV) was evaluated using Spearman correlations.

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The impact of methodological and temporal variation on infarct size quantification in acute myocardial infarction with late enhancement CMR

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