The impairment of insulin signaling in Alzheimer's disease

Emanuel Candeias, Ana I Duarte, Cristina Carvalho, Sónia C Correia, Susana Cardoso, Renato X Santos, Ana I Plácido, George Perry, Paula I Moreira

Research output: Contribution to journalReview articlepeer-review

58 Citations (Scopus)


Alterations of the insulin signaling cascade underlie cognitive decline and the development of several neurodegenerative diseases. In recent years, a great interest has been put in studying the interaction between diabetes and Alzheimer's disease (AD). In fact, evidence shows that both diseases present several biochemical similarities including defects in the insulin signaling pathway. Here, we give an overview of the main functions of insulin in the central nervous system. The impact of insulin signaling impairment in brain aging and AD is also discussed. Finally, we present evidence supporting the notion that insulin is a link between diabetes and AD.

Original languageEnglish
Pages (from-to)951-957
Number of pages7
JournalIUBMB life
Issue number12
Early online date6 Nov 2012
Publication statusPublished - Dec 2012

Bibliographical note

Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.
ACKNOWLEDGEMENTS The authors are grateful to Fundacao para a Ciencia e a Tecnologia (FCT, project PTDC/SAU-TOX/117481/2010; PTDC/SAU-NMC/110990/2009; PTDC/SAU-NEU/103325/2008), Po-tugal and Programa de Estı muloa Investigacao da Faculdade de Medicina, Universidade de Coimbra, Portugal (PMADSC/2011) for financial support.


  • Aging
  • Alzheimer Disease/genetics
  • Brain/metabolism
  • Diabetes Mellitus/genetics
  • Gene Expression
  • Glucose/metabolism
  • Humans
  • Insulin/genetics
  • Insulin Resistance
  • Insulin-Like Growth Factor I/genetics
  • Mitochondria/metabolism
  • Neurons/metabolism
  • Receptor, IGF Type 1/genetics
  • Risk Factors
  • Signal Transduction


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