The interaction between a HSP-70 gene variant with dietary calories in determining serum markers of inflammation and cardiovascular risk

Mehrane Mehramiz, Seyed Mahdi Hassanian, Maryam Mardan-Nik, Alireza Pasdar, Khadijeh Jamialahmadi, Hamid Fiuji, Mehrdad Moetamani-Ahmadi, Seyed Mohammad Reza Parizadeh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mahmoud Ebrahimi, Gordon A. Ferns, Majid Ghayour-Mobarhan* (Corresponding Author), Amir Avan* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Background: The high prevalence of cardiovascular disease (CVD) globally is attributable to an interaction between environmental and genetic factors. Gene × diet interaction studies aim to explore how a modifiable factor interacts with genetic predispositions. Here we have explored the interaction of a heat shock protein (HSP70) gene polymorphism (+1267A > G) with dietary intake and their possible association with serum C-reactive protein (CRP), an inflammatory marker, that is a major component of CVD risk. Methods: HSP70 genotype was determined using a TaqMan real time PCR based method.Dietary intake was assessed using a dietary questionnaire. Serum high sensitivity (Hs) CRP and other cardiovascular risk factors were assessed by routine methods. This included coronary angioplasty to determine the presence of coronary artery stenosis. Results: There were significant differences between serum lipid profile and Hs-CRP across the genotypes for Hsp70. The carriers of G allele had higher serum hs-CRP concentrations, compared with the AA homozygotes, with the wild genotype. Interaction analysis showed the association was modulated by total energy intake; the interaction of high energy intake with GG genotype: RERI = 0.77, AP = 0.26, S = 1.6. Conclusion: We have found a significant association between the +1267A > G variant of the HSP70 gene with cardiovascular risk factors and serum hs-CRP concentrations. It is possible that a low energy diet could ameliorate the unfavorable effects of G allele of HSP70.

Original languageEnglish
Pages (from-to)2122-2126
Number of pages5
JournalClinical Nutrition
Issue number6
Early online date24 Oct 2017
Publication statusPublished - Dec 2018

Bibliographical note

Funding Information:
Grant: This study was support by a grant from Mashhad University of Medical Sciences (960933, 960705, 940263).

Publisher Copyright:
© 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism


  • Cardiovascular disease
  • Chronic disease
  • Gene/diet interaction
  • HSP70
  • Inflammation


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