Gut microbiota can be manipulated to benefit host health, including the use of probiotics, prebiotics and synbiotics. This Consensus Statement outlines the definition and scope of the term 'synbiotics' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in May 2019.
In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to "a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host". The panel concluded that defining synbiotics as simply a mixture of probiotics and prebiotics could suppress the innovation of synbiotics that are designed to function cooperatively. Requiring that each component must meet the evidence and dose requirements for probiotics and prebiotics individually could also present an obstacle. Rather, the panel clarified that a complementary synbiotic, which has not been designed so that its component parts function cooperatively, must be composed of a probiotic plus a prebiotic, whereas a synergistic synbiotic does not need to be so. A synergistic synbiotic is a synbiotic for which the substrate is designed to be selectively utilized by the co-administered microorganisms. This Consensus Statement further explores the levels of evidence (existing and required), safety, effects upon targets and implications for stakeholders of the synbiotic concept.
This panel was supported by the International Scientific Association for Probiotics and Prebiotics (ISAPP), a not-for-profit organization dedicated to advancing the science of probiotics and prebiotics. ISAPP’s activities are determined by its volunteer board of directors, comprising academic scientists. Through its Industry Advisory Committee, ISAPP incorporates industry scientists in its activities and raises funds. ISAPP strives to be an objective, science-based voice for the probiotic and prebiotic fields. The content of this paper was reviewed and approved by the ISAPP board of directors. The Rowett Institute (K.P.S.) receives financial support from the Scottish Government (RESAS).
- RANDOMIZED CLINICAL-TRIAL
- FATTY LIVER-DISEASE
- GUT MICROBIOTA
- OXIDATIVE STRESS
- POSTOPERATIVE COMPLICATIONS
- INFECTIOUS COMPLICATIONS