The Janus Face of Insulin in Brain

Ana I Duarte; Emanuel  Candeias; Sónia C Correia; Renato X. Santos; Cristina Carvalho; Susana Cardoso; Ana I Plácido; Maria Sancha Santos; Catarina R Oliveira; Paula Isabel da Silva Moreira

doi:10.1002/9781118395318.ch5

The Janus Face of Insulin in Brain

Ana I Duarte , Emanuel Candeias, Sónia C Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I Plácido, Maria Sancha Santos, Catarina R Oliveira, Paula Isabel da Silva Moreira

University of Coimbra

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.

Original language	English
Title of host publication	Metabolic Syndrome and Neurological Disorders
Editors	Tahira Farooqui, Akhlaq A. Farooqui
Publisher	John Wiley & Sons Ltd.
Chapter	5
Pages	85-113
Number of pages	29
ISBN (Electronic)	9781118395318
ISBN (Print)	9781118395271
DOIs	https://doi.org/10.1002/9781118395318.ch5
Publication status	Published - 15 Nov 2013
Externally published	Yes

Keywords

Alzheimer disease (AD)
brain
central nervous system (CNS)
diabetes
insulin
neurodegeneration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/9781118395318.ch5Licence: Unspecified

Cite this

Duarte , A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & da Silva Moreira, P. I. (2013). The Janus Face of Insulin in Brain. In T. Farooqui, & A. A. Farooqui (Eds.), Metabolic Syndrome and Neurological Disorders (pp. 85-113). John Wiley & Sons Ltd.. https://doi.org/10.1002/9781118395318.ch5

@inbook{a2b762c7317e4850934b63374fcd530e,

title = "The Janus Face of Insulin in Brain",

abstract = "Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.",

keywords = "Alzheimer disease (AD), brain, central nervous system (CNS), diabetes, insulin, neurodegeneration",

author = "Duarte, {Ana I} and Emanuel Candeias and Correia, {S{\'o}nia C} and Santos, {Renato X.} and Cristina Carvalho and Susana Cardoso and Pl{\'a}cido, {Ana I} and Santos, {Maria Sancha} and Oliveira, {Catarina R} and {da Silva Moreira}, {Paula Isabel}",

year = "2013",

month = nov,

day = "15",

doi = "10.1002/9781118395318.ch5",

language = "English",

isbn = "9781118395271",

pages = "85--113",

editor = "Tahira Farooqui and Farooqui, {Akhlaq A.}",

booktitle = "Metabolic Syndrome and Neurological Disorders",

publisher = "John Wiley & Sons Ltd.",

address = "United Kingdom",

}

TY - CHAP

T1 - The Janus Face of Insulin in Brain

AU - Duarte , Ana I

AU - Candeias, Emanuel

AU - Correia, Sónia C

AU - Santos, Renato X.

AU - Carvalho, Cristina

AU - Cardoso, Susana

AU - Plácido, Ana I

AU - Santos, Maria Sancha

AU - Oliveira, Catarina R

AU - da Silva Moreira, Paula Isabel

PY - 2013/11/15

Y1 - 2013/11/15

N2 - Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.

AB - Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.

KW - Alzheimer disease (AD)

KW - brain

KW - central nervous system (CNS)

KW - diabetes

KW - insulin

KW - neurodegeneration

U2 - 10.1002/9781118395318.ch5

DO - 10.1002/9781118395318.ch5

M3 - Chapter

SN - 9781118395271

SP - 85

EP - 113

BT - Metabolic Syndrome and Neurological Disorders

A2 - Farooqui, Tahira

A2 - Farooqui, Akhlaq A.

PB - John Wiley & Sons Ltd.

ER -

The Janus Face of Insulin in Brain

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this