The Janus Face of Insulin in Brain

Ana I Duarte; Emanuel  Candeias; Sónia C Correia; Renato X. Santos; Cristina Carvalho; Susana Cardoso; Ana I Plácido; Maria Sancha Santos; Catarina R Oliveira; Paula Isabel da Silva Moreira

doi:10.1002/9781118395318.ch5

The Janus Face of Insulin in Brain

Ana I Duarte , Emanuel Candeias, Sónia C Correia, Renato X. Santos, Cristina Carvalho, Susana Cardoso, Ana I Plácido, Maria Sancha Santos, Catarina R Oliveira, Paula Isabel da Silva Moreira

University of Coimbra

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.

Original language	English
Title of host publication	Metabolic Syndrome and Neurological Disorders
Editors	Tahira Farooqui, Akhlaq A. Farooqui
Publisher	John Wiley & Sons Ltd.
Chapter	5
Pages	85-113
Number of pages	29
ISBN (Electronic)	9781118395318
ISBN (Print)	9781118395271
DOIs	https://doi.org/10.1002/9781118395318.ch5
Publication status	Published - 15 Nov 2013

Keywords

Alzheimer disease (AD)
brain
central nervous system (CNS)
diabetes
insulin
neurodegeneration

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/9781118395318.ch5Licence: Unspecified

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Duarte , A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & da Silva Moreira, P. I. (2013). The Janus Face of Insulin in Brain. In T. Farooqui, & A. A. Farooqui (Eds.), Metabolic Syndrome and Neurological Disorders (pp. 85-113). John Wiley & Sons Ltd.. https://doi.org/10.1002/9781118395318.ch5

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abstract = "Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.",

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AU - Duarte , Ana I

AU - Candeias, Emanuel

AU - Correia, Sónia C

AU - Santos, Renato X.

AU - Carvalho, Cristina

AU - Cardoso, Susana

AU - Plácido, Ana I

AU - Santos, Maria Sancha

AU - Oliveira, Catarina R

AU - da Silva Moreira, Paula Isabel

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AB - Important studies recently reported that insulin exerts a neuroprotective effect and that decreased brain insulin levels and/or insulin and its receptors (IR)‐mediated signaling are linked to several age‐related neurodegenerative diseases. These findings were further potentiated by the recent hypothesis that insulin may constitute the potential missing link between diabetes and Alzheimer disease (AD) in the central nervous system (CNS), resulting in AD being called “type 3 diabetes.” In this regard, insulin could be a very promising therapy against diabetes‐ and age‐related neurodegenerative diseases. However, some studies (including longevity ones) have given controversial results on the beneficial effects of CNS insulin/IR activity. Herewith, the authors aim to critically analyze the pros and cons of insulin in the CNS, especially regarding age‐ and diabetes‐related neurodegeneration.

KW - Alzheimer disease (AD)

KW - brain

KW - central nervous system (CNS)

KW - diabetes

KW - insulin

KW - neurodegeneration

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BT - Metabolic Syndrome and Neurological Disorders

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A2 - Farooqui, Akhlaq A.

PB - John Wiley & Sons Ltd.

ER -

The Janus Face of Insulin in Brain

Abstract

Keywords

UN SDGs

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