The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

N. A. Weaver; L. Zhao; J. M. Biesbroek; H. J. Kuijf; H. P. Aben; H. J. Bae; M. A. A. Caballero; F. M. Chappell; Cplh Chen; M. Dichgans; M. Duering; M. K. Georgakis; R. S. van der Giessen; B. Gyanwali; O. K. L. Hamilton; S. Hilal; E. M. Vom Hofe; P. L. M. de Kort; P. J. Koudstaal; B. Y. K. Lam; J. S. Lim; S. D. J. Makin; V. C. T. Mok; L. Shi; M. C. Valdes Hernandez; N. Venketasubramanian; J. M. Wardlaw; F. A. Wollenweber; A. Wong; X. Xin; V. C. I. Map consortium Meta; G. J. Biessels

doi:10.1016/j.dadm.2019.02.007

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

N. A. Weaver, L. Zhao, J. M. Biesbroek, H. J. Kuijf, H. P. Aben, H. J. Bae, M. A. A. Caballero, F. M. Chappell, Cplh Chen, M. Dichgans, M. Duering, M. K. Georgakis, R. S. van der Giessen, B. Gyanwali, O. K. L. Hamilton, S. Hilal, E. M. Vom Hofe, P. L. M. de Kort, P. J. Koudstaal, B. Y. K. LamJ. S. Lim, S. D. J. Makin, V. C. T. Mok, L. Shi, M. C. Valdes Hernandez, N. Venketasubramanian, J. M. Wardlaw, F. A. Wollenweber, A. Wong, X. Xin, V. C. I. Map consortium Meta, G. J. Biessels

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Abstract

Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

Original language	English
Pages (from-to)	310-326
Number of pages	17
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	11
Early online date	12 Apr 2019
DOIs	https://doi.org/10.1016/j.dadm.2019.02.007
Publication status	Published - Dec 2019

Bibliographical note

Additional grant support pilot study cohorts: The CODECS study is supported by a grant from Stichting Coolsingel, the Netherlands. Funding for the PROCRAS study was obtained through ZonMw as part of the ‘TopZorg’ project in 2015 (grant # 842003011). The CU-STRIDE study was funded by the Health and Health Services Research Fund (0708041) of the Food and Health Bureau of the Government of the Hong Kong Special Administrative Region. The CU-RISK study was funded by General Research Fund (grant number GRF CUHK 471911), the National Key Research and Development Program of China (grant number 2016YFC1300600), and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Center for Prevention of Dementia (in memory of Donald H. K. Chow). The Mild Stroke Study 2 was funded by the Wellcome Trust (WT088134/Z/09/A), the Row Fogo Charitable Trust and Chest Heart & Stroke Scotland (long-term follow-up, ref no: Res14/A157). J.M.W. is supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (ref no. 16 CVD 05) and the UK Dementia Research Institute at The University of Edinburgh. O.K.L.H. is supported by the College of Medicine and Veterinary Medicine at the University of Edinburgh and the Wellcome Trust.

Keywords

Cerebrovascular disease Consortium Data harmonization Lesion location Lesion-symptom mapping Small vessel disease Stroke Support vector regression Vascular cognitive impairment
Lesion-symptom mapping
Stroke
Small vessel disease
Lesion location
Vascular cognitive impairment
Consortium
Support vector regression
Data harmonization
Cerebrovascular disease

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Weaver, N. A., Zhao, L., Biesbroek, J. M., Kuijf, H. J., Aben, H. P., Bae, H. J., Caballero, M. A. A., Chappell, F. M., Chen, C., Dichgans, M., Duering, M., Georgakis, M. K., van der Giessen, R. S., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Vom Hofe, E. M., de Kort, P. L. M., Koudstaal, P. J., ... Biessels, G. J. (2019). The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 11, 310-326. https://doi.org/10.1016/j.dadm.2019.02.007

The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. / Weaver, N. A.; Zhao, L.; Biesbroek, J. M. et al.
In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol. 11, 12.2019, p. 310-326.

Research output: Contribution to journal › Article › peer-review

Weaver, NA, Zhao, L, Biesbroek, JM, Kuijf, HJ, Aben, HP, Bae, HJ, Caballero, MAA, Chappell, FM, Chen, C, Dichgans, M, Duering, M, Georgakis, MK, van der Giessen, RS, Gyanwali, B, Hamilton, OKL, Hilal, S, Vom Hofe, EM, de Kort, PLM, Koudstaal, PJ, Lam, BYK, Lim, JS, Makin, SDJ, Mok, VCT, Shi, L, Valdes Hernandez, MC, Venketasubramanian, N, Wardlaw, JM, Wollenweber, FA, Wong, A, Xin, X, Meta, VCIMC & Biessels, GJ 2019, 'The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study', Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, vol. 11, pp. 310-326. https://doi.org/10.1016/j.dadm.2019.02.007

Weaver NA, Zhao L, Biesbroek JM, Kuijf HJ, Aben HP, Bae HJ et al. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2019 Dec;11:310-326. Epub 2019 Apr 12. doi: 10.1016/j.dadm.2019.02.007

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title = "The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study",

abstract = "Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.",

keywords = "Cerebrovascular disease Consortium Data harmonization Lesion location Lesion-symptom mapping Small vessel disease Stroke Support vector regression Vascular cognitive impairment, Lesion-symptom mapping, Stroke, Small vessel disease, Lesion location, Vascular cognitive impairment, Consortium, Support vector regression, Data harmonization, Cerebrovascular disease",

author = "Weaver, {N. A.} and L. Zhao and Biesbroek, {J. M.} and Kuijf, {H. J.} and Aben, {H. P.} and Bae, {H. J.} and Caballero, {M. A. A.} and Chappell, {F. M.} and Cplh Chen and M. Dichgans and M. Duering and Georgakis, {M. K.} and {van der Giessen}, {R. S.} and B. Gyanwali and Hamilton, {O. K. L.} and S. Hilal and {Vom Hofe}, {E. M.} and {de Kort}, {P. L. M.} and Koudstaal, {P. J.} and Lam, {B. Y. K.} and Lim, {J. S.} and Makin, {S. D. J.} and Mok, {V. C. T.} and L. Shi and {Valdes Hernandez}, {M. C.} and N. Venketasubramanian and Wardlaw, {J. M.} and Wollenweber, {F. A.} and A. Wong and X. Xin and Meta, {V. C. I. Map consortium} and Biessels, {G. J.}",

note = "Additional grant support pilot study cohorts: The CODECS study is supported by a grant from Stichting Coolsingel, the Netherlands. Funding for the PROCRAS study was obtained through ZonMw as part of the {\textquoteleft}TopZorg{\textquoteright} project in 2015 (grant # 842003011). The CU-STRIDE study was funded by the Health and Health Services Research Fund (0708041) of the Food and Health Bureau of the Government of the Hong Kong Special Administrative Region. The CU-RISK study was funded by General Research Fund (grant number GRF CUHK 471911), the National Key Research and Development Program of China (grant number 2016YFC1300600), and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Center for Prevention of Dementia (in memory of Donald H. K. Chow). The Mild Stroke Study 2 was funded by the Wellcome Trust (WT088134/Z/09/A), the Row Fogo Charitable Trust and Chest Heart & Stroke Scotland (long-term follow-up, ref no: Res14/A157). J.M.W. is supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (ref no. 16 CVD 05) and the UK Dementia Research Institute at The University of Edinburgh. O.K.L.H. is supported by the College of Medicine and Veterinary Medicine at the University of Edinburgh and the Wellcome Trust. ",

year = "2019",

month = dec,

doi = "10.1016/j.dadm.2019.02.007",

language = "English",

volume = "11",

pages = "310--326",

journal = "Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring",

issn = "2352-8729",

publisher = "Elsevier",

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T1 - The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping

T2 - Design and multicenter pilot study

AU - Weaver, N. A.

AU - Zhao, L.

AU - Biesbroek, J. M.

AU - Kuijf, H. J.

AU - Aben, H. P.

AU - Bae, H. J.

AU - Caballero, M. A. A.

AU - Chappell, F. M.

AU - Chen, Cplh

AU - Dichgans, M.

AU - Duering, M.

AU - Georgakis, M. K.

AU - van der Giessen, R. S.

AU - Gyanwali, B.

AU - Hamilton, O. K. L.

AU - Hilal, S.

AU - Vom Hofe, E. M.

AU - de Kort, P. L. M.

AU - Koudstaal, P. J.

AU - Lam, B. Y. K.

AU - Lim, J. S.

AU - Makin, S. D. J.

AU - Mok, V. C. T.

AU - Shi, L.

AU - Valdes Hernandez, M. C.

AU - Venketasubramanian, N.

AU - Wardlaw, J. M.

AU - Wollenweber, F. A.

AU - Wong, A.

AU - Xin, X.

AU - Meta, V. C. I. Map consortium

AU - Biessels, G. J.

N1 - Additional grant support pilot study cohorts: The CODECS study is supported by a grant from Stichting Coolsingel, the Netherlands. Funding for the PROCRAS study was obtained through ZonMw as part of the ‘TopZorg’ project in 2015 (grant # 842003011). The CU-STRIDE study was funded by the Health and Health Services Research Fund (0708041) of the Food and Health Bureau of the Government of the Hong Kong Special Administrative Region. The CU-RISK study was funded by General Research Fund (grant number GRF CUHK 471911), the National Key Research and Development Program of China (grant number 2016YFC1300600), and the Lui Che Woo Institute of Innovative Medicine, and Therese Pei Fong Chow Research Center for Prevention of Dementia (in memory of Donald H. K. Chow). The Mild Stroke Study 2 was funded by the Wellcome Trust (WT088134/Z/09/A), the Row Fogo Charitable Trust and Chest Heart & Stroke Scotland (long-term follow-up, ref no: Res14/A157). J.M.W. is supported by the Fondation Leducq Transatlantic Network of Excellence for the Study of Perivascular Spaces in Small Vessel Disease (ref no. 16 CVD 05) and the UK Dementia Research Institute at The University of Edinburgh. O.K.L.H. is supported by the College of Medicine and Veterinary Medicine at the University of Edinburgh and the Wellcome Trust.

PY - 2019/12

Y1 - 2019/12

N2 - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

AB - Introduction: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Methods: Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Results: Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Discussion: Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

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KW - Stroke

KW - Small vessel disease

KW - Lesion location

KW - Vascular cognitive impairment

KW - Consortium

KW - Support vector regression

KW - Data harmonization

KW - Cerebrovascular disease

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The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

Abstract

Bibliographical note

Keywords

UN SDGs

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