The pathophysiology of diastolic heart failure

Thanh Trung Phan, Michael Frenneaux

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Whilst resting disturbances of both diastolic and long-axis systolic function are observed in patients with heart failure who have normal left ventricular ejection fraction, recent evidence suggests that dynamic disturbances in cardiac function occur during exercise. A paradoxical slowing of left ventricular active relaxation during exercise limits cardiac filling and therefore stroke volume and appears to be due to the combination of cardiac energetic impairment and disturbed ventricular-vascular coupling.
Original languageEnglish
Article number16
Number of pages4
JournalF1000 Biology Reports
Publication statusPublished - 24 Feb 2010


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