The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

C. M. Loos, C. McHutchison, V. Cvoro, S. D. Makin, J. Staals, F. Chappell, M.S. Dennis, R. J. van Oostenbrugge, J. M. Wardlaw

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Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact of total cerebral small vessel disease-related brain damage, expressed by a cerebral small vessel disease MRI burden score, on mobility after stroke, has not been considered, although this score gives a better representation of the overall effect of cerebral small vessel disease on the brain. We determined if the total cerebral small vessel disease burden is associated with gait impairment three years after minor stroke. Methods In total, 200 patients with minor lacunar or non-lacunar stroke (NIHSS
Original languageEnglish
Pages (from-to)518-524
Number of pages7
JournalInternational Journal of Stroke
Issue number5
Early online date1 Jul 2018
Publication statusPublished - 2018

Bibliographical note

We thank the patients and their families, and the staff of the Brain Research Imaging Centre, Edinburgh, where MRI scanning was performed.
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Mild Stroke Study-2 follow up study at three years was funded by Chest Heart Stroke Scotland. The original MSS-2 study was funded by the Wellcome Trust (ref. 088134/Z/09/A) and Row Fogo Charitable Trust. The imaging was performed at the Brain Research Imaging Centre Edinburgh, which is supported by the SINAPSE collaboration and the Chief Scientist Office of the Scottish Government ( The work was supported by European Union Horizon 2020 (EU H2020), PHC03-15, project No 666881, ’SVDs@Target’, and the Fondation Leducq Transatlantic Network of Excellence for Study of Perivascular Spaces in Small Vessel Disease, ref no. 16 CVD 05. The work reflects the views of the authors and not of the funders. CMJL was supported by the Dutch Alzheimer Foundation and VC holds a NHS Research Scotland Fellowship. The work was performed in the Edinburgh Dementia Research Centre in the UK DementiaResearch Initiative


  • Cerebal small vessel disease
  • minor stroke
  • total cerebal small vessel disease burden
  • gait impairment
  • stroke impact scale
  • functional outcome


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