The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

C. M. Loos; C. McHutchison; V. Cvoro; S. D. Makin; J. Staals; F. Chappell; M.S.  Dennis; R. J. van Oostenbrugge; J. M. Wardlaw

doi:10.1177/1747493017730780

The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

C. M. Loos, C. McHutchison, V. Cvoro, S. D. Makin, J. Staals, F. Chappell, M.S. Dennis, R. J. van Oostenbrugge, J. M. Wardlaw

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

10 Downloads (Pure)

Abstract

Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact of total cerebral small vessel disease-related brain damage, expressed by a cerebral small vessel disease MRI burden score, on mobility after stroke, has not been considered, although this score gives a better representation of the overall effect of cerebral small vessel disease on the brain. We determined if the total cerebral small vessel disease burden is associated with gait impairment three years after minor stroke. Methods In total, 200 patients with minor lacunar or non-lacunar stroke (NIHSS

Original language	English
Pages (from-to)	518-524
Number of pages	7
Journal	International Journal of Stroke
Volume	13
Issue number	5
Early online date	1 Jul 2018
DOIs	https://doi.org/10.1177/1747493017730780
Publication status	Published - 2018

Bibliographical note

Acknowledgements
We thank the patients and their families, and the staff of the Brain Research Imaging Centre, Edinburgh, where MRI scanning was performed.
Funding
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Mild Stroke Study-2 follow up study at three years was funded by Chest Heart Stroke Scotland. The original MSS-2 study was funded by the Wellcome Trust (ref. 088134/Z/09/A) and Row Fogo Charitable Trust. The imaging was performed at the Brain Research Imaging Centre Edinburgh, which is supported by the SINAPSE collaboration and the Chief Scientist Office of the Scottish Government (http://www.bric.ed.ac.uk/). The work was supported by European Union Horizon 2020 (EU H2020), PHC03-15, project No 666881, ’SVDs@Target’, and the Fondation Leducq Transatlantic Network of Excellence for Study of Perivascular Spaces in Small Vessel Disease, ref no. 16 CVD 05. The work reflects the views of the authors and not of the funders. CMJL was supported by the Dutch Alzheimer Foundation and VC holds a NHS Research Scotland Fellowship. The work was performed in the Edinburgh Dementia Research Centre in the UK DementiaResearch Initiative

Keywords

Cerebal small vessel disease
minor stroke
total cerebal small vessel disease burden
gait impairment
stroke impact scale
functional outcome

Access to Document

10.1177/1747493017730780Licence: CC BY

Loos-et-al-relation-between-international-journal-of-stroke-vor
This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
Final published version, 2.21 MBLicence: CC BY

https://www.ncbi.nlm.nih.gov/pubmed/28906203

Stephen Makin
- School of Medicine, Medical Sciences & Nutrition, Applied Health Sciences - Senior Lecturer (Clinical)
Person: Clinical Academic

Cite this

@article{13ea2f3d47944f6c8480266ba35b9ee8,

title = "The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke",

abstract = "Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact of total cerebral small vessel disease-related brain damage, expressed by a cerebral small vessel disease MRI burden score, on mobility after stroke, has not been considered, although this score gives a better representation of the overall effect of cerebral small vessel disease on the brain. We determined if the total cerebral small vessel disease burden is associated with gait impairment three years after minor stroke. Methods In total, 200 patients with minor lacunar or non-lacunar stroke (NIHSS ",

keywords = "Cerebal small vessel disease, minor stroke, total cerebal small vessel disease burden, gait impairment, stroke impact scale, functional outcome",

author = "Loos, {C. M.} and C. McHutchison and V. Cvoro and Makin, {S. D.} and J. Staals and F. Chappell and M.S. Dennis and {van Oostenbrugge}, {R. J.} and Wardlaw, {J. M.}",

note = "Acknowledgements We thank the patients and their families, and the staff of the Brain Research Imaging Centre, Edinburgh, where MRI scanning was performed. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Mild Stroke Study-2 follow up study at three years was funded by Chest Heart Stroke Scotland. The original MSS-2 study was funded by the Wellcome Trust (ref. 088134/Z/09/A) and Row Fogo Charitable Trust. The imaging was performed at the Brain Research Imaging Centre Edinburgh, which is supported by the SINAPSE collaboration and the Chief Scientist Office of the Scottish Government (http://www.bric.ed.ac.uk/). The work was supported by European Union Horizon 2020 (EU H2020), PHC03-15, project No 666881, {\textquoteright}SVDs@Target{\textquoteright}, and the Fondation Leducq Transatlantic Network of Excellence for Study of Perivascular Spaces in Small Vessel Disease, ref no. 16 CVD 05. The work reflects the views of the authors and not of the funders. CMJL was supported by the Dutch Alzheimer Foundation and VC holds a NHS Research Scotland Fellowship. The work was performed in the Edinburgh Dementia Research Centre in the UK DementiaResearch Initiative",

year = "2018",

doi = "10.1177/1747493017730780",

language = "English",

volume = "13",

pages = "518--524",

journal = "International Journal of Stroke",

issn = "1747-4949",

publisher = "SAGE Publications Ltd STM",

number = "5",

}

TY - JOUR

T1 - The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

AU - Loos, C. M.

AU - McHutchison, C.

AU - Cvoro, V.

AU - Makin, S. D.

AU - Staals, J.

AU - Chappell, F.

AU - Dennis, M.S.

AU - van Oostenbrugge, R. J.

AU - Wardlaw, J. M.

N1 - Acknowledgements We thank the patients and their families, and the staff of the Brain Research Imaging Centre, Edinburgh, where MRI scanning was performed. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The Mild Stroke Study-2 follow up study at three years was funded by Chest Heart Stroke Scotland. The original MSS-2 study was funded by the Wellcome Trust (ref. 088134/Z/09/A) and Row Fogo Charitable Trust. The imaging was performed at the Brain Research Imaging Centre Edinburgh, which is supported by the SINAPSE collaboration and the Chief Scientist Office of the Scottish Government (http://www.bric.ed.ac.uk/). The work was supported by European Union Horizon 2020 (EU H2020), PHC03-15, project No 666881, ’SVDs@Target’, and the Fondation Leducq Transatlantic Network of Excellence for Study of Perivascular Spaces in Small Vessel Disease, ref no. 16 CVD 05. The work reflects the views of the authors and not of the funders. CMJL was supported by the Dutch Alzheimer Foundation and VC holds a NHS Research Scotland Fellowship. The work was performed in the Edinburgh Dementia Research Centre in the UK DementiaResearch Initiative

PY - 2018

Y1 - 2018

N2 - Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact of total cerebral small vessel disease-related brain damage, expressed by a cerebral small vessel disease MRI burden score, on mobility after stroke, has not been considered, although this score gives a better representation of the overall effect of cerebral small vessel disease on the brain. We determined if the total cerebral small vessel disease burden is associated with gait impairment three years after minor stroke. Methods In total, 200 patients with minor lacunar or non-lacunar stroke (NIHSS

AB - Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact of total cerebral small vessel disease-related brain damage, expressed by a cerebral small vessel disease MRI burden score, on mobility after stroke, has not been considered, although this score gives a better representation of the overall effect of cerebral small vessel disease on the brain. We determined if the total cerebral small vessel disease burden is associated with gait impairment three years after minor stroke. Methods In total, 200 patients with minor lacunar or non-lacunar stroke (NIHSS

KW - Cerebal small vessel disease

KW - minor stroke

KW - total cerebal small vessel disease burden

KW - gait impairment

KW - stroke impact scale

KW - functional outcome

U2 - 10.1177/1747493017730780

DO - 10.1177/1747493017730780

M3 - Article

SN - 1747-4949

VL - 13

SP - 518

EP - 524

JO - International Journal of Stroke

JF - International Journal of Stroke

IS - 5

ER -

The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Profiles

Stephen Makin

Cite this