The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Mohammad Reza Mirinezhad; Hamideh Ghazizadeh; Maliheh Aghsizadeh; Mohammad Zamiri Bidary; Alireza Naghipour; Elahe Hasanzadeh; Mahdiyeh Yaghooti-Khorasani; Ali Ebrahimi Dabagh; Mohammad Reza Shadmand Foumani Moghadam; Nazanin Sheikh Andalibi; Zeynab Naseri Far; Habibollah Esmaily; Gordon A. Ferns; Tayebeh Hamzehloei; Alireza Pasdar; Majid Ghayour-Mobarhan

doi:10.1186/s12905-021-01550-8

The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Mohammad Reza Mirinezhad, Hamideh Ghazizadeh, Maliheh Aghsizadeh, Mohammad Zamiri Bidary, Alireza Naghipour, Elahe Hasanzadeh, Mahdiyeh Yaghooti-Khorasani, Ali Ebrahimi Dabagh, Mohammad Reza Shadmand Foumani Moghadam, Nazanin Sheikh Andalibi, Zeynab Naseri Far, Habibollah Esmaily, Gordon A. Ferns, Tayebeh Hamzehloei, Alireza Pasdar^* (Corresponding Author), Majid Ghayour-Mobarhan^* (Corresponding Author)

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background and aim: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors.

Methods: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed.

Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03).

Conclusion: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

Original language	English
Article number	2
Number of pages	12
Journal	BMC Women's Health
Volume	22
Early online date	7 Jan 2022
DOIs	https://doi.org/10.1186/s12905-021-01550-8
Publication status	Published - Dec 2022

Bibliographical note

Acknowledgements:
We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250).

Funding Information:
Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran.

Data Availability Statement

The data that support the findings of this study are available from the corresponding author upon reasonable request.

Keywords

ARMS-PCR
ASO-PCR
Cardiovascular disease
Primary Ovarian Insufficiency

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Mirinezhad, M. R., Ghazizadeh, H., Aghsizadeh, M., Zamiri Bidary, M., Naghipour, A., Hasanzadeh, E., Yaghooti-Khorasani, M., Ebrahimi Dabagh, A., Moghadam, M. R. S. F., Sheikh Andalibi, N., Naseri Far, Z., Esmaily, H., Ferns, G. A., Hamzehloei, T., Pasdar, A., & Ghayour-Mobarhan, M. (2022). The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study. BMC Women's Health, 22, Article 2. https://doi.org/10.1186/s12905-021-01550-8

Mirinezhad, MR, Ghazizadeh, H, Aghsizadeh, M, Zamiri Bidary, M, Naghipour, A, Hasanzadeh, E, Yaghooti-Khorasani, M, Ebrahimi Dabagh, A, Moghadam, MRSF, Sheikh Andalibi, N, Naseri Far, Z, Esmaily, H, Ferns, GA, Hamzehloei, T, Pasdar, A & Ghayour-Mobarhan, M 2022, 'The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study', BMC Women's Health, vol. 22, 2. https://doi.org/10.1186/s12905-021-01550-8

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title = "The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study",

abstract = "Background and aim: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.",

keywords = "ARMS-PCR, ASO-PCR, Cardiovascular disease, Primary Ovarian Insufficiency",

author = "Mirinezhad, {Mohammad Reza} and Hamideh Ghazizadeh and Maliheh Aghsizadeh and {Zamiri Bidary}, Mohammad and Alireza Naghipour and Elahe Hasanzadeh and Mahdiyeh Yaghooti-Khorasani and {Ebrahimi Dabagh}, Ali and Moghadam, {Mohammad Reza Shadmand Foumani} and {Sheikh Andalibi}, Nazanin and {Naseri Far}, Zeynab and Habibollah Esmaily and Ferns, {Gordon A.} and Tayebeh Hamzehloei and Alireza Pasdar and Majid Ghayour-Mobarhan",

note = "Acknowledgements: We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250). Funding Information: Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran. ",

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doi = "10.1186/s12905-021-01550-8",

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T1 - The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

AU - Mirinezhad, Mohammad Reza

AU - Ghazizadeh, Hamideh

AU - Aghsizadeh, Maliheh

AU - Zamiri Bidary, Mohammad

AU - Naghipour, Alireza

AU - Hasanzadeh, Elahe

AU - Yaghooti-Khorasani, Mahdiyeh

AU - Ebrahimi Dabagh, Ali

AU - Moghadam, Mohammad Reza Shadmand Foumani

AU - Sheikh Andalibi, Nazanin

AU - Naseri Far, Zeynab

AU - Esmaily, Habibollah

AU - Ferns, Gordon A.

AU - Hamzehloei, Tayebeh

AU - Pasdar, Alireza

AU - Ghayour-Mobarhan, Majid

N1 - Acknowledgements: We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250). Funding Information: Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran.

PY - 2022/12

Y1 - 2022/12

N2 - Background and aim: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

AB - Background and aim: Primary Ovarian Insufficiency (POI) is defined by the occurrence of menopause before the age of 40 years. It is often associated with cardiovascular disease (CVD). The purpose of this study was to explore the relationship between POI-associated genotypes cardiometabolic disorder risk factors. Methods: One hundred seventeen women with POI and one hundred eighty-three healthy women without POI were recruited in this study. DNA was extracted and analyzed using ASO-PCR or Tetra ARMS-PCR. Lipid profiles were also assessed. Results: Multivariate logistic regression analysis showed that individuals with GG vs. TT genotype of the rs1046089 SNP were more likely to have a higher serum LDL (p = 0.03) compared to the control group. There was also a significant association between low serum HDL and rs2303369 and rs4806660 SNP genotypes in the POI group. In the POI group, the percentage of those with high total cholesterol was lower in those with a CC genotype compared to those with a TT genotype (p = 0.03). Conclusion: Some SNPs reported to be associated with POI appear to be independently associated with dyslipidemia. These results may be helpful to identify subjects with POI who may be susceptible to CVD.

KW - ARMS-PCR

KW - ASO-PCR

KW - Cardiovascular disease

KW - Primary Ovarian Insufficiency

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DO - 10.1186/s12905-021-01550-8

M3 - Article

C2 - 34996442

AN - SCOPUS:85122656734

SN - 1472-6874

VL - 22

JO - BMC Women's Health

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M1 - 2

ER -

The relationship between genetic variants associated with primary ovarian insufficiency and lipid profile in women recruited from MASHAD cohort study

Abstract

Bibliographical note

Data Availability Statement

Keywords

UN SDGs

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