The relevance of heat shock regulation in fungal pathogens of humans

Alistair James Petersen Brown; Michelle Leach; Susan Melanie Nicholls

doi:10.4161/viru.1.4.12364

The relevance of heat shock regulation in fungal pathogens of humans

Alistair James Petersen Brown, Michelle Leach, Susan Melanie Nicholls

Medical Sciences

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.

Original language	English
Pages (from-to)	330-332
Number of pages	3
Journal	Virulence
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/viru.1.4.12364
Publication status	Published - Jul 2010

Bibliographical note

A paid open access option is available for this journal.
Authors final version only, Publisher's version/PDF may be used upon payment of Open Access fee

Keywords

heat shock response
Hsf1
Hsp90
transcriptional regulation
fungal pathogenesis
fungal morphogenesis

Access to Document

10.4161/viru.1.4.12364

Cite this

@article{df8e696ad9094e6486a2f759dc07ee18,

title = "The relevance of heat shock regulation in fungal pathogens of humans",

abstract = "Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans. ",

keywords = "heat shock response, Hsf1, Hsp90, transcriptional regulation, fungal pathogenesis, fungal morphogenesis",

author = "Brown, {Alistair James Petersen} and Michelle Leach and Nicholls, {Susan Melanie}",

note = "A paid open access option is available for this journal. Authors final version only, Publisher's version/PDF may be used upon payment of Open Access fee",

year = "2010",

month = jul,

doi = "10.4161/viru.1.4.12364",

language = "English",

volume = "1",

pages = "330--332",

journal = "Virulence",

issn = "2150-5594",

publisher = "Landes Bioscience",

number = "4",

}

TY - JOUR

T1 - The relevance of heat shock regulation in fungal pathogens of humans

AU - Brown, Alistair James Petersen

AU - Leach, Michelle

AU - Nicholls, Susan Melanie

N1 - A paid open access option is available for this journal. Authors final version only, Publisher's version/PDF may be used upon payment of Open Access fee

PY - 2010/7

Y1 - 2010/7

N2 - Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.

AB - Despite being obligately associated with warm-blooded animals, Candida albicans expresses a bona fide heat shock response that is regulated by the evolutionarily conserved, essential heat shock transcription factor Hsf1. Hsf1 is thought to play a fundamental role in thermal homeostasis, adjusting the levels of essential chaperones to changes in growth temperature, for example in febrile patients. Hsf1 also regulates the expression of Hsp90, which controls the yeast-hypha transition in C. albicans, and we argue, might also control morphogenesis in other fungal pathogens of humans.

KW - heat shock response

KW - Hsf1

KW - Hsp90

KW - transcriptional regulation

KW - fungal pathogenesis

KW - fungal morphogenesis

U2 - 10.4161/viru.1.4.12364

DO - 10.4161/viru.1.4.12364

M3 - Article

SN - 2150-5594

VL - 1

SP - 330

EP - 332

JO - Virulence

JF - Virulence

IS - 4

ER -

The relevance of heat shock regulation in fungal pathogens of humans

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this