The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Mohlopheni J Marakalala; Reto Guler; Lungile Matika; Graeme Murray; Muazzam Jacobs; Frank Brombacher; Antonio Gigliotti Rothfuchs; Alan Sher; Gordon D Brown

doi:10.1016/j.micinf.2010.10.013

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Mohlopheni J Marakalala, Reto Guler, Lungile Matika, Graeme Murray, Muazzam Jacobs, Frank Brombacher, Antonio Gigliotti Rothfuchs, Alan Sher, Gordon D Brown

Applied Medicine

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.

Original language	English
Pages (from-to)	198-201
Number of pages	4
Journal	Microbes and Infection
Volume	13
Issue number	2
Early online date	27 Oct 2010
DOIs	https://doi.org/10.1016/j.micinf.2010.10.013
Publication status	Published - Feb 2011

Keywords

adaptor proteins, signal transducing
animals
cytokines
female
immunity, innate
membrane proteins
mice
mice, knockout
Mycobacterium tuberculosis
nerve tissue proteins
nuclear proteins
tuberculosis, pulmonary

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.micinf.2010.10.013

Cite this

@article{87195cd2301946c8a8ff0895734da33f,

title = "The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice",

abstract = "There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.",

keywords = "adaptor proteins, signal transducing, animals, cytokines, female, immunity, innate, membrane proteins, mice, mice, knockout, Mycobacterium tuberculosis, nerve tissue proteins, nuclear proteins, tuberculosis, pulmonary",

author = "Marakalala, {Mohlopheni J} and Reto Guler and Lungile Matika and Graeme Murray and Muazzam Jacobs and Frank Brombacher and Rothfuchs, {Antonio Gigliotti} and Alan Sher and Brown, {Gordon D}",

year = "2011",

month = feb,

doi = "10.1016/j.micinf.2010.10.013",

language = "English",

volume = "13",

pages = "198--201",

journal = "Microbes and Infection",

issn = "1769-714X",

publisher = "Elsevier Masson SAS",

number = "2",

}

TY - JOUR

T1 - The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

AU - Marakalala, Mohlopheni J

AU - Guler, Reto

AU - Matika, Lungile

AU - Murray, Graeme

AU - Jacobs, Muazzam

AU - Brombacher, Frank

AU - Rothfuchs, Antonio Gigliotti

AU - Sher, Alan

AU - Brown, Gordon D

PY - 2011/2

Y1 - 2011/2

N2 - There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.

AB - There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.

KW - adaptor proteins, signal transducing

KW - animals

KW - cytokines

KW - female

KW - immunity, innate

KW - membrane proteins

KW - mice

KW - mice, knockout

KW - Mycobacterium tuberculosis

KW - nerve tissue proteins

KW - nuclear proteins

KW - tuberculosis, pulmonary

U2 - 10.1016/j.micinf.2010.10.013

DO - 10.1016/j.micinf.2010.10.013

M3 - Article

C2 - 21034845

SN - 1769-714X

VL - 13

SP - 198

EP - 201

JO - Microbes and Infection

JF - Microbes and Infection

IS - 2

ER -

The Syk/CARD9-coupled receptor Dectin-1 is not required for host resistance to Mycobacterium tuberculosis in mice

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this