The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

Catriona J Cunningham; Elena Redondo-Castro; Stuart M Allan

doi:10.1177/0271678x18776802

The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

Catriona J Cunningham, Elena Redondo-Castro, Stuart M Allan^* (Corresponding Author)

^*Corresponding author for this work

Medical Sciences

University of Manchester

Research output: Contribution to journal › Review article › peer-review

183 Citations (Scopus)

8 Downloads (Pure)

Abstract

Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called “bystander” effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia.

Original language	English
Pages (from-to)	1276-1292
Number of pages	18
Journal	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume	38
Issue number	8
Early online date	18 May 2018
DOIs	https://doi.org/10.1177/0271678x18776802
Publication status	Published - 1 Aug 2018

Bibliographical note

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by an EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine studentship grant The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by an EPSRC and MRC Centre for Doctoral Training in Regenerative Medicine studentship grant EP/L014904/1.

Keywords

cell therapy
mesenchymal stem cell
repair
stroke
secretome

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The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke. / Cunningham, Catriona J; Redondo-Castro, Elena; Allan, Stuart M (Corresponding Author).
In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 38, No. 8, 01.08.2018, p. 1276-1292.

Research output: Contribution to journal › Review article › peer-review

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abstract = "Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called “bystander” effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia.",

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The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

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Keywords

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