Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)

Paola E J van der Meijden; Yukio Ozaki; Wolfram Ruf; Bas de Laat; Nicola Mutch; Scott Diamond; Rienk Nieuwland; Tessa C Peters; Marco Heestermans; Romy M W Kremers; Martijn Moorlag; Johan Boender; Betül Ünlü; Pieter H Reitsma

doi:10.1016/j.thromres.2015.07.034

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)

Paola E J van der Meijden, Yukio Ozaki, Wolfram Ruf, Bas de Laat, Nicola Mutch, Scott Diamond, Rienk Nieuwland, Tessa C Peters, Marco Heestermans, Romy M W Kremers, Martijn Moorlag, Johan Boender, Betül Ünlü, Pieter H Reitsma

Medical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

One in every four deaths is due to thrombosis [1]. This thrombosis occurs in the arterial system as myocardial infarction and stroke, but also often in the venous system in the form of deep vein thrombosis or pulmonary embolism, collectively termed venous thromboembolism (VTE). The annual frequency of VTE is 1-2 per 1,000 per year [2]. The incidence has a very steep age gradient such that the young are rarely affected, whereas it is very common in the old, in particular in combination with co-morbidities such as chronic inflammatory disease and cancer.

The mechanistic framework that helps to understand and explain the causes of VTE is based on Virchow’s triad [3]. This triad postulates that blood flow, the state of the vessel wall and the composition of the blood represent the three main determinants of whether a thrombotic event will occur or not. In arterial thrombosis the state of the vessel wall is the strongest determinant, whereas in venous thrombosis it is the composition of the blood.

Original language	English
Pages (from-to)	S3-S7
Number of pages	5
Journal	Thrombosis Research
Volume	136
Issue number	Suppl 1
Early online date	19 Sept 2015
DOIs	https://doi.org/10.1016/j.thromres.2015.07.034
Publication status	Published - Sept 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.thromres.2015.07.034Licence: Unspecified

Cite this

van der Meijden, P. E. J., Ozaki, Y., Ruf, W., de Laat, B., Mutch, N., Diamond, S., Nieuwland, R., Peters, T. C., Heestermans, M., Kremers, R. M. W., Moorlag, M., Boender, J., Ünlü, B., & Reitsma, P. H. (2015). Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). Thrombosis Research, 136 (Suppl 1), S3-S7. https://doi.org/10.1016/j.thromres.2015.07.034

@article{d09e3bf0fbaf479aafa55ab473ff1a9e,

title = "Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)",

abstract = "One in every four deaths is due to thrombosis [1]. This thrombosis occurs in the arterial system as myocardial infarction and stroke, but also often in the venous system in the form of deep vein thrombosis or pulmonary embolism, collectively termed venous thromboembolism (VTE). The annual frequency of VTE is 1-2 per 1,000 per year [2]. The incidence has a very steep age gradient such that the young are rarely affected, whereas it is very common in the old, in particular in combination with co-morbidities such as chronic inflammatory disease and cancer.The mechanistic framework that helps to understand and explain the causes of VTE is based on Virchow{\textquoteright}s triad [3]. This triad postulates that blood flow, the state of the vessel wall and the composition of the blood represent the three main determinants of whether a thrombotic event will occur or not. In arterial thrombosis the state of the vessel wall is the strongest determinant, whereas in venous thrombosis it is the composition of the blood.",

author = "{van der Meijden}, {Paola E J} and Yukio Ozaki and Wolfram Ruf and {de Laat}, Bas and Nicola Mutch and Scott Diamond and Rienk Nieuwland and Peters, {Tessa C} and Marco Heestermans and Kremers, {Romy M W} and Martijn Moorlag and Johan Boender and Bet{\"u}l {\"U}nl{\"u} and Reitsma, {Pieter H}",

year = "2015",

month = sep,

doi = "10.1016/j.thromres.2015.07.034",

language = "English",

volume = "136 ",

pages = "S3--S7",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Limited",

number = "Suppl 1",

}

TY - JOUR

T1 - Theme 1

T2 - Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)

AU - van der Meijden, Paola E J

AU - Ozaki, Yukio

AU - Ruf, Wolfram

AU - de Laat, Bas

AU - Mutch, Nicola

AU - Diamond, Scott

AU - Nieuwland, Rienk

AU - Peters, Tessa C

AU - Heestermans, Marco

AU - Kremers, Romy M W

AU - Moorlag, Martijn

AU - Boender, Johan

AU - Ünlü, Betül

AU - Reitsma, Pieter H

PY - 2015/9

Y1 - 2015/9

N2 - One in every four deaths is due to thrombosis [1]. This thrombosis occurs in the arterial system as myocardial infarction and stroke, but also often in the venous system in the form of deep vein thrombosis or pulmonary embolism, collectively termed venous thromboembolism (VTE). The annual frequency of VTE is 1-2 per 1,000 per year [2]. The incidence has a very steep age gradient such that the young are rarely affected, whereas it is very common in the old, in particular in combination with co-morbidities such as chronic inflammatory disease and cancer.The mechanistic framework that helps to understand and explain the causes of VTE is based on Virchow’s triad [3]. This triad postulates that blood flow, the state of the vessel wall and the composition of the blood represent the three main determinants of whether a thrombotic event will occur or not. In arterial thrombosis the state of the vessel wall is the strongest determinant, whereas in venous thrombosis it is the composition of the blood.

AB - One in every four deaths is due to thrombosis [1]. This thrombosis occurs in the arterial system as myocardial infarction and stroke, but also often in the venous system in the form of deep vein thrombosis or pulmonary embolism, collectively termed venous thromboembolism (VTE). The annual frequency of VTE is 1-2 per 1,000 per year [2]. The incidence has a very steep age gradient such that the young are rarely affected, whereas it is very common in the old, in particular in combination with co-morbidities such as chronic inflammatory disease and cancer.The mechanistic framework that helps to understand and explain the causes of VTE is based on Virchow’s triad [3]. This triad postulates that blood flow, the state of the vessel wall and the composition of the blood represent the three main determinants of whether a thrombotic event will occur or not. In arterial thrombosis the state of the vessel wall is the strongest determinant, whereas in venous thrombosis it is the composition of the blood.

U2 - 10.1016/j.thromres.2015.07.034

DO - 10.1016/j.thromres.2015.07.034

M3 - Article

C2 - 26387733

SN - 0049-3848

VL - 136

SP - S3-S7

JO - Thrombosis Research

JF - Thrombosis Research

IS - Suppl 1

ER -

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome)

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this