Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

A. Sharma; N. L. Sharma; C. B. Lavy; A. E. Kiltie; F. C. Hamdy; J. Czernuszka

doi:10.1007/s10853-014-8325-x

Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

A. Sharma, N. L. Sharma^*, C. B. Lavy, A. E. Kiltie, F. C. Hamdy, J. Czernuszka

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

University of Oxford

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the variety of materials available, obstacles remain to perfecting an in vitro model system and we outline some of the challenges yet to be overcome.

Original language	English
Pages (from-to)	5809-5820
Number of pages	12
Journal	Journal of Materials Science
Volume	49
Issue number	17
DOIs	https://doi.org/10.1007/s10853-014-8325-x
Publication status	Published - Sept 2014

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title = "Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology",

abstract = "Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the variety of materials available, obstacles remain to perfecting an in vitro model system and we outline some of the challenges yet to be overcome.",

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T2 - An in vitro strategy for the biomimetic modelling of in vivo tumour biology

AU - Sharma, A.

AU - Sharma, N. L.

AU - Lavy, C. B.

AU - Kiltie, A. E.

AU - Hamdy, F. C.

AU - Czernuszka, J.

PY - 2014/9

Y1 - 2014/9

N2 - Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the variety of materials available, obstacles remain to perfecting an in vitro model system and we outline some of the challenges yet to be overcome.

AB - Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the variety of materials available, obstacles remain to perfecting an in vitro model system and we outline some of the challenges yet to be overcome.

UR - http://www.scopus.com/inward/record.url?scp=84903550923&partnerID=8YFLogxK

U2 - 10.1007/s10853-014-8325-x

DO - 10.1007/s10853-014-8325-x

M3 - Review article

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VL - 49

SP - 5809

EP - 5820

JO - Journal of Materials Science

JF - Journal of Materials Science

IS - 17

ER -

Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

Abstract

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