Thrombophilia in pregnancy: a systematic review

L Robertson, O Wu, P Langhorne, S Twaddle, P Clark, G D O Lowe, I D Walker, M Greaves, I Brenkel, L Regan, I A Greer, Thrombosis Screening Study

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709 Citations (Scopus)


Growing evidence suggests that thrombophilia is associated with venous thromboembolism (VTE) and adverse pregnancy outcomes. However, methodological limitations have made it difficult to obtain a clear overview of the overall risks. We conducted a systematic review to determine the risk of VTE and adverse pregnancy outcomes associated with thrombophilia in pregnancy. The effectiveness of prophylactic interventions during pregnancy was also evaluated. Major electronic databases were searched, relevant data abstracted and study quality assessed by two independent reviewers. Odds ratios (ORs) stratified by thrombophilia type were calculated for each outcome. A total of 79 studies were included in our review. The risks for individual thrombophilic defects were determined for VTE (ORs, 0.74-34.40); early pregnancy loss (ORs, 1.40-6.25); late pregnancy loss (ORs, 1.31-20.09); pre-eclampsia (ORs, 1.37-3.49); placental abruption (ORs, 1.42-7.71) and intrauterine growth restriction (ORs, 1.24-2.92). Low-dose aspirin plus heparin was the most effective in preventing pregnancy loss in thrombophilic women (OR, 1.62). Our findings confirm that women with thrombophilia are at risk of developing VTE and complications in pregnancy. However, despite the increase in relative risk, the absolute risk of VTE and adverse outcomes remains low. There is also a lack of controlled trials of antithrombotic intervention to prevent pregnancy complications. Thus, at present, universal screening for thrombophilia in pregnancy cannot be justified clinically.

Original languageEnglish
Pages (from-to)171-196
Number of pages26
JournalBritish Journal of Haematology
Issue number2
Early online date15 Nov 2005
Publication statusPublished - Jan 2006


  • thrombophilia
  • pregnancy outcomes
  • systematic review
  • factor-v-leiden
  • protein-C resistance
  • methylenetetrahydrofolate reductase gene
  • recurrent miscarriage population
  • randomized controlled-trial
  • molecular-weight heparin
  • low-dose aspirin
  • late fetal loss
  • antiphospholipid antibodies
  • risk-factor


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