Towards a cure for osteoporosis: the UK Royal Osteoporosis Society (ROS) Osteoporosis Research Roadmap

Nicholas C Harvey* (Corresponding Author), Kenneth E. S. Poole, Stuart H Ralston, Eugene V. McCloskey, Caroline B Sangan, Lauren Wiggins, Craig I. Jones, Neil Gittoes, Juliet Compston, ROS Osteoporosis and Bone Research Academy Investigators

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
7 Downloads (Pure)


Purpose / Introduction
The Royal Osteoporosis Society (ROS) Osteoporosis and Bone Research Academy
(Academy) was launched by HRH Duchess of Cornwall in February 2019, with a core mission to identify key gaps in osteoporosis research and service provision, and to undertake novel research projects towards a cure for osteoporosis, as documented in the ROS Osteoporosis Research Roadmap.
The Academy comprises an Advisory Committee and three synergistic Working Groups: Causes, Effectiveness and Technology. Through a series of workshops supported by ROS, together with extensive patient insight, the Working Groups undertook focused rapid evidence reviews to identify key gaps in osteoporosis research and clinical care, subsequently developing targeted work streams addressing these gaps.
Priority areas for further research have been identified in three interlinked areas; associated work plans, with major synergies between Working Groups, have been developed. Themes include: 1) genetic and non-genetic causes of low bone mass, underlying mechanisms, lessons from rare diseases and consequent development of new and better treatments; 2) novel technologies for opportunistic detection of vertebral fractures, new measures of bone strength, and big data analyses to detect novel risk factors and develop new algorithms; 3)
optimisation of the effectiveness of assessment and treatment through automated fracture risk assessment, personalised therapeutic approaches and optimised care pathways.
This unique initiative has proposed new strategies to address current evidential gaps in osteoporosis. The resulting workplan will guide ROS funding initiatives and has the potential to achieve a step change in tackling the global burden of fragility fractures, ensuring optimisation of population bone health across the lifecourse with appropriate identification, assessment and treatment of all individuals at high risk of fracture.

The UK Royal Osteoporosis Society (ROS) Osteoporosis and Bone Research Academy has undertaken a comprehensive assessment of the current gaps in the osteoporosis evidence base and proposed an integrated workplan to address these evidential needs
Original languageEnglish
Article number12
Number of pages6
JournalArchives of Osteoporosis
Early online date6 Jan 2022
Publication statusPublished - Dec 2022

Bibliographical note

We are hugely grateful to the Royal Osteoporosis Society staff for their continued support of the ROS Academy, in particular Lauren Wiggins, Caroline Sangan, Jamie Grier, Craig Jones and previously Belinda Thompson, Francesca Thompson, Fizz Thompson and Claire Severgnini, together with the invaluable contribution of the ROS Academy Patient Advocates, and in particular Nic Vine and Mary Bishop for the detailed review and feedback on this article.


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