Toxic epidermal necrolysis treated with cyclosporin

J Hewitt, Anthony Ormerod

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67 Citations (Scopus)


Toxic epidermal necrolysis (TEN) is a severe life-threatening disorder which has many features in common with graft-versus-host disease. However, immunosuppression with steroids gives disappointing results and is possibly detrimental. We treated two patients who had TEN with a combination of cyclosporin and steroids which resulted in an apparent halt to the evolution of the disease, and a further relapse was aborted using cyclosporin in one of these patients. We feel that the use of this drug in the early treatment of TEN where it is used as a specific therapy aimed at the primary immunopathological events and is used in conjunction with the supportive care patients require, needs to be further evaluated.
Original languageEnglish
Pages (from-to)264-265
Number of pages2
JournalClinical and Experimental Dermatology
Issue number4
Publication statusPublished - 1 Jul 1992


  • Adult
  • Cyclosporine
  • Drug Therapy, Combination
  • Epidermal Necrolysis, Toxic
  • Female
  • Humans
  • Liver
  • Prednisolone


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